Evidence map›Paper›PMID 29259116›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Mixed signature of activation and dysfunction allows human decidual CD8

Anita van der Zwan, Kevin Bi, Errol R Norwitz, Ângela C Crespo, Frans H J Claas, Jack L Strominger, Tamara Tilburgs

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06281262 (The Role of Selected Immunological Indicators and Microbiota in Patients Experiencing Premature Birth and Preeclampsia), which is not on this map. Cited by 92 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06281262 unknown statusnot on this mapstarted 2023, after this paper: background citation

The Role of Selected Immunological Indicators and Microbiota in Patients Experiencing Premature Birth and Preeclampsia

TypeobservationalSponsorGeneral University Hospital, PragueRan2023 to 2025Enrolled100ConditionsPreterm Birth, PreeclampsiaArmsPeripheral blood collection, Swab sample collection
3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 1 synthesis or guideline pooled it, 146 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Joining the dots: maternal cytomegalovirus, HIV and the placenta.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Systemic and Local Immunological Markers in Preeclampsia.Diagnostics (Basel, Switzerland) · 2025
    Article
  15. Review
  16. Review
  17. The landscape of decidual immune cells at the maternal-fetal interface in parturition and preterm birth.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
  18. A vaccine against cytomegalovirus: how close are we?The Journal of clinical investigation · 2025
    Article
  19. Review
  20. Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Anita van der ZwanDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138.
Kevin BiDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Children's Hospital, Boston, MA 02115.
Errol R NorwitzDepartment of Obstetrics & Gynecology, Tufts Medical Center, Boston, MA 02111.
Ângela C CrespoDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138.ORCID 0000-0002-6731-8190
Frans H J ClaasDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Jack L StromingerDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138; jlstrom@fas.harvard.edu tilburgs@fas.harvard.edu.
Tamara TilburgsDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138; jlstrom@fas.harvard.edu tilburgs@fas.harvard.edu.
Harvard University · USBoston Children's Hospital · USDana-Farber Cancer Institute · USLeiden University Medical Center · NLTufts Medical Center · US

Funding

Human Decidual Lymphocytes and their Placental LigandsR01AI053330 · NIAID · HARVARD UNIVERSITY · PI STROMINGER, JACK L · 2003 to 2014
$4.1M
Human Decidual Leukocytes and Their Placental LigandsR56AI053330 · NIAID · HARVARD UNIVERSITY · PI STROMINGER, JACK L · 2009 to 2009
$415k
NIAID NIH HHS R01 AI053330NIAID NIH HHS R56 AI053330
6 · The paper itself

Abstract

Understanding how decidual CD8

Indexed as

CD8-Positive T-LymphocytesCytomegalovirusCytomegalovirus InfectionsDeciduaFemaleGene Expression ProfilingGranzymesHumansImmune ToleranceLymphocyte ActivationPerforinTime FactorsGranzymesPerforincytotoxicityplacentapregnancyT cell exhaustiontrophoblast

Identifiers

PMID29259116
PMCPMC5777048
OpenAlexW2778453835

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.