Evidence map›Paper›PMID 29259096›Full record

ArticleThe Journal of cell biology2018

Control of microtubule dynamics using an optogenetic microtubule plus end-F-actin cross-linker.

Rebecca C Adikes, Ryan A Hallett, Brian F Saway, Brian Kuhlman, Kevin C Slep

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
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  3. Review
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  5. Article
  6. Review
  7. Journal of the American Chemical Society · 2022
    Article
  8. Article
  9. Review
  10. Article
  11. New twists in actin-microtubule interactions.Molecular biology of the cell · 2021
    Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Actin-microtubule crosstalk in cell biology.Nature reviews. Molecular cell biology · 2019
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Rebecca C AdikesDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Ryan A HallettDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Brian F SawayDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0002-7101-0981
Brian KuhlmanDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Kevin C SlepDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC kslep@bio.unc.edu.ORCID 0000-0003-2365-6080
University of North Carolina at Chapel Hill · US

Funding

MOLECULAR AND CELLULAR BIOPHYSICS TRAINING PROGRAMT32GM008570 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KUHLMAN, BRIAN A, SLEP, KEVIN C · 1995 to 2022
$5.1M
Spatiotemporal Control of the Epigenome via Photoactivatable Nuclear LocalizationR01DA036877 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAHN, KLAUS M., KUHLMAN, BRIAN A · 2013 to 2017
$2.1M
Design of Genetically Encoded Photoactivatable ProteinsR01GM093208 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KUHLMAN, BRIAN A · 2010 to 2013
$1.1M
Molecular Mechanisms of Cytoskeletal RegulatorsR01GM094415 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROGERS, STEPHEN, SLEP, KEVIN C · 2011 to 2014
$1.1M
Molecular Mechanisms of SpectraplakinsR03HD084980 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SLEP, KEVIN C · 2015 to 2016
$147k
Investigating the role of the Drosophila XMAP215 family member, Mini spindles, at centrosomes and kinetochore microtubule plus ends during mitosisF31GM116476 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ADIKES, REBECCA C · 2016 to 2017
$68k
NICHD NIH HHS R03 HD084980NIDA NIH HHS R01 DA036877NIGMS NIH HHS F31 GM116476NIGMS NIH HHS R01 GM093208NIGMS NIH HHS R01 GM094415NIGMS NIH HHS T32 GM008570
6 · The paper itself

Abstract

We developed a novel optogenetic tool, SxIP-improved light-inducible dimer (iLID), to facilitate the reversible recruitment of factors to microtubule (MT) plus ends in an end-binding protein-dependent manner using blue light. We show that SxIP-iLID can track MT plus ends and recruit tgRFP-SspB upon blue light activation. We used this system to investigate the effects of cross-linking MT plus ends and F-actin in

Indexed as

OptogeneticsActinsAnimalsCells, CulturedCross-Linking ReagentsDrosophila melanogasterMicrotubulesActinsCross-Linking Reagents

Identifiers

PMID29259096
PMCPMC5800807
OpenAlexW2950883167

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.