Evidence map›Paper›PMID 29259080›Full record

ArticleThe Biochemical journal2018

Identification of a second binding site on the TRIM25 B30.2 domain.

Akshay A D'Cruz, Nadia J Kershaw, Thomas J Hayman, Edmond M Linossi, Jessica J Chiang, May K Wang, Laura F Dagley, Tatiana B Kolesnik, Jian-Guo Zhang, Seth L Masters and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Biochemical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Targeting TRIM Proteins: A Quest towards Drugging an Emerging Protein Class.Chembiochem : a European journal of chemical biology · 2021
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Akshay A D'CruzThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Nadia J KershawThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Thomas J HaymanThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Edmond M LinossiThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Jessica J ChiangDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, U. S. A.
May K WangDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, U. S. A.
Laura F DagleyThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Tatiana B KolesnikThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Jian-Guo ZhangThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Seth L MastersThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Michael D W GriffinThe University of Melbourne, Parkville, Victoria, Australia.
Michaela U GackDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, U. S. A.
James M MurphyThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Nicos A NicolaThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Jeffrey J BabonThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Sandra E NicholsonThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia snicholson@wehi.edu.au.ORCID 0000-0002-1314-2134

Funding

Regulation of Host Innate Immunity Against Viral InfectionR01AI087846 · NIAID · UNIVERSITY OF CHICAGO · PI GACK, MICHAELA ULRIKE · 2010 to 2020
$3.9M
NIAID NIH HHS R01 AI087846
6 · The paper itself

Abstract

The

Indexed as

Sequence DeletionAmino Acid SequenceAnimalsB30.2-SPRY DomainBinding SitesCaspase Activation and Recruitment DomainCloning, MolecularCrystallography, X-RayDEAD Box Protein 58Escherichia coliGenetic VectorsGlutathione TransferaseHEK293 CellsHistidineHumansMiceDEAD Box Protein 58FLAG peptideGlutathione TransferaseHis-His-His-His-His-HisHistidineOligopeptidesReceptors, Cytoplasmic and NuclearReceptors, ImmunologicRecombinant Fusion ProteinsRecombinant ProteinsRIGI protein, humanB30.2interferonRIG-ITRIMTRIM25

Identifiers

PMID29259080
PMCPMC6200327

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.