Evidence map›Paper›PMID 29259051›Full record

ArticleRNA (New York, N.Y.)2018

Widespread temperature sensitivity and tRNA decay due to mutations in a yeast tRNA.

Matthew J Payea, Michael F Sloma, Yoshiko Kon, David L Young, Michael P Guy, Xiaoju Zhang, Thareendra De Zoysa, Stanley Fields, David H Mathews, Eric M Phizicky

Abstract read
In one paragraph

Article in RNA (New York, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. RNA modifying enzymes shape tRNA biogenesis and function.The Journal of biological chemistry · 2024
    Review
  4. Review
  5. Estimating RNA Secondary Structure Folding Free Energy Changes with efn2.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  6. The life and times of a tRNA.RNA (New York, N.Y.) · 2023
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Matthew J Payea *Department of Biochemistry and Biophysics and Center for RNA Biology, University of Rochester School of Medicine, Rochester, New York 14642, USA.
Michael F Sloma *Department of Biochemistry and Biophysics and Center for RNA Biology, University of Rochester School of Medicine, Rochester, New York 14642, USA.
Yoshiko Kon *Department of Biochemistry and Biophysics and Center for RNA Biology, University of Rochester School of Medicine, Rochester, New York 14642, USA.
David L YoungDepartment of Genome Sciences, University of Washington, Seattle, Washington 98195, USA.
Michael P GuyDepartment of Biochemistry and Biophysics and Center for RNA Biology, University of Rochester School of Medicine, Rochester, New York 14642, USA.
Xiaoju ZhangDepartment of Biochemistry and Biophysics and Center for RNA Biology, University of Rochester School of Medicine, Rochester, New York 14642, USA.
Thareendra De ZoysaDepartment of Biochemistry and Biophysics and Center for RNA Biology, University of Rochester School of Medicine, Rochester, New York 14642, USA.
Stanley FieldsDepartment of Genome Sciences, University of Washington, Seattle, Washington 98195, USA.
David H MathewsDepartment of Biochemistry and Biophysics and Center for RNA Biology, University of Rochester School of Medicine, Rochester, New York 14642, USA.
Eric M PhizickyDepartment of Biochemistry and Biophysics and Center for RNA Biology, University of Rochester School of Medicine, Rochester, New York 14642, USA.

Funding

University of Washington Medical Scientist Training Program: MD/PhDT32GM007266 · NIGMS · UNIVERSITY OF WASHINGTON · PI HORWITZ, MARSHALL S. · 1985 to 2023
$30.4M
TrainingP41GM103533 · NIGMS · UNIVERSITY OF WASHINGTON · PI MACCOSS, MICHAEL · 2012 to 2021
$20.7M
TRNA SPLICINGR01GM052347 · NIGMS · UNIVERSITY OF ROCHESTER · PI Eric M. Phizicky · 1995 to 2026
$9.6M
Supporting RNAstructure: Software for RNA AnalysisR01GM076485 · NIGMS · UNIVERSITY OF ROCHESTER · PI MATHEWS, DAVID H. · 2006 to 2021
$4.7M
Howard Hughes Medical InstituteNIGMS NIH HHS P41 GM103533NIGMS NIH HHS R01 GM052347NIGMS NIH HHS R01 GM076485NIGMS NIH HHS T32 GM007266
6 · The paper itself

Abstract

Microorganisms have universally adapted their RNAs and proteins to survive at a broad range of temperatures and growth conditions. However, for RNAs, there is little quantitative understanding of the effects of mutations on function at high temperatures. To understand how variant tRNA function is affected by temperature change, we used the tRNA nonsense suppressor

Indexed as

Gene LibraryGenes, ReporterMutationPeptide Termination FactorsRNA StabilityRNA, TransferSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSequence Analysis, DNATemperaturePeptide Termination FactorsRNA, TransferSaccharomyces cerevisiae ProteinsSUP45 protein, S cerevisiaenonsense suppressorRNA temperature sensitivitySUP4thermal stabilitytRNAtRNA decay

Identifiers

PMID29259051
PMCPMC5824359

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.