ArticleThe British journal of ophthalmology2018
Genetic risk factors for late age-related macular degeneration in India.
Article in The British journal of ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Linking the microbiome to the complement system in geographic atrophy.NPJ genomic medicine · 2026Article
- Impact of age-related maculopathy susceptibility 2, high-temperature requirement A serine peptidase 1, and complement factor H genetic variants on clinical phenotypes of age-related macular degeneration.Indian journal of ophthalmology · 2026Article
- From cooperation to collapse: the diet-microbiota-host gene triad in disease and aging.Frontiers in microbiomes · 2026Review
- Polymorphism rs11200638 enhanced HtrA1 responsiveness and expression are associated with age-related macular degeneration.Eye (London, England) · 2022Article
- Review
- Genotyping of Clinical Parameters in Age-Related Macular Degeneration.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Optimized Prediction Models from Fundus Imaging and Genetics for Late Age-Related Macular Degeneration.Journal of personalized medicine · 2021Article
- Associations ofClinical ophthalmology (Auckland, N.Z.) · 2021Article
- Haplotypes ofDisease markers · 2019Article
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Authors and funding
10 authors.
Funding
Abstract
BACKGROUND/
aimsThere are limited data from India on genetic variants influencing late age-related macular degeneration (AMD). We have previously reported associations from a population-based study in India (the India age-related eye disease study (INDEYE)) of early AMD and single nucleotide polymorphisms (SNPs) in
methodsFundus images of late AMD hospital cases were independently graded by the modified Wisconsin AMD grading scheme. In total 510 cases with late AMD (14 geographic atrophy and 496 neovascular AMD (nvAMD)), 1876 with early AMD and 1176 with no signs of AMD underwent genotyping for selected SNPs. We investigated genotype and per-allele additive associations (OR and 95% CIs) with nvAMD or early AMD. Bonferroni adjusted P values are presented.
resultsWe found associations with nvAMD for
conclusionsThe major genetic determinants of nvAMD risk in India are similar to those in other ancestries, while findings for early AMD suggest potential differences in the pathophysiology of AMD development.
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