ArticleJournal of the American Academy of Dermatology2018
Fibrous cephalic plaques in tuberous sclerosis complex.
Article in Journal of the American Academy of Dermatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 25 citations in OpenAlex.
- High prevalence of orocutaneous features in Yemeni patients with tuberous sclerosis complex.JAAD international · 2026Article
- Uncommon Large and Bilateral Fibrous Cephalic Plaques in a Patient withChildren (Basel, Switzerland) · 2023Article
- Multiple fibrofolliculomas within a fibrous cephalic plaque in a patient with tuberous sclerosis.JAAD case reports · 2023Article
- Histopathological features of fibrous cephalic plaques in tuberous sclerosis complex.Histopathology · 2021Article
- Article
- Miliary fibromas in tuberous sclerosis complex.Journal of the European Academy of Dermatology and Venereology : JEADV · 2021Article
- Early Sirolimus Gel Treatment May Diminish Angiofibromas and Prevent Angiofibroma Recurrence in Children With Tuberous Sclerosis Complex.Frontiers in medicine · 2020Article
- Natural history of a fibrous cephalic plaque and sustained eight decade follow-up in an 80 year old with tuberous sclerosis complex type 2.The Ulster medical journal · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundFibrous cephalic plaques (FCPs) stereotypically develop on the forehead of patients with tuberous sclerosis complex (TSC). They constitute a major feature for TSC diagnosis and may present before other TSC-related cutaneous hamartomas.
objectiveTo describe the clinical characteristics of FCPs in TSC.
methodsA total of 113 patients with TSC were enrolled in an observational cohort study. Retrospective analysis of medical records and skin photography was performed. FCPs were categorized by anatomic location and size.
resultsFCPs were observed in 36% of patients (41 of 113). Of 62 total lesions, 58% were 1 to less than 5 cm, 13% were 5 cm or larger, and 29% were of unknown size mostly because of prior excision. The distribution of lesions was 39% on the forehead, 27% on the face (nonforehead), 3% on the neck, and 31% on the scalp. Fourteen patients had similar lesions less than 1 cm in diameter. Histopathologically, FCPs displayed dermal collagenosis, decreased elastic fibers, and features of angiofibromas or fibrofolliculomas. LIMITATIONS: Men were under-represented because the cohort was enriched for patients with TSC with lymphangioleiomyomatosis, which occurs in adult women.
conclusionTwo-fifths of FCPs presented on the forehead, with most of the remainder in other locations on the face and scalp. Better recognition of these lesions may lead to earlier diagnosis of TSC.
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