Evidence map›Paper›PMID 29258678›Full record

Trial reportClinical nutrition (Edinburgh, Scotland)2018

Effects of alternate-day fasting or daily calorie restriction on body composition, fat distribution, and circulating adipokines: Secondary analysis of a randomized controlled trial.

John F Trepanowski, Cynthia M Kroeger, Adrienne Barnosky, Monica Klempel, Surabhi Bhutani, Kristin K Hoddy, Jennifer Rood, Eric Ravussin, Krista A Varady

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical nutrition (Edinburgh, Scotland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 86 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 14 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00960505 nacompletednot on this map

Alternate Day Fasting for Weight Loss, Weight Maintenance and Cardio-protection

TypeinterventionalSponsorUniversity of Illinois at ChicagoRan2010 to 2015Enrolled100ConditionsCoronary Heart Disease, Obesity, Weight LossArmsAlternate day fasting, Calorie restriction, Control diet
NCT04133701 nacompletednot on this mapstarted 2022, after this paper: background citation

The Impact of Meal Timing on Neurovascular Control in Adults

TypeinterventionalSponsorUniversity of Wisconsin, MadisonRan2022 to 2022Enrolled34ConditionsBlood Pressure, Neurovascular ControlArmsTime-Restricted Feeding
3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 14 syntheses or guidelines pooled it, 142 citations in OpenAlex.

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  12. The Influence of Fasting and Energy Restricting Diets on Blood Pressure in Humans: A Systematic Review and Meta-Analysis.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2020
    Pooled it
  13. Intermittent fasting and weight loss: Systematic review.Canadian family physician Medecin de famille canadien · 2020
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26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

John F TrepanowskiDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA; Stanford Prevention Research Center, Stanford University, Stanford, CA, USA. Electronic address: jtrepa2@stanford.edu.
Cynthia M KroegerDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA; Department of Epidemiology and Biostatistics, Indiana University School of Public Health-Bloomington, Bloomington, IN, USA.
Adrienne BarnoskyDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.
Monica KlempelDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.
Surabhi BhutaniDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.
Kristin K HoddyDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.
Jennifer RoodNutrition and Obesity Division, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Eric RavussinNutrition and Obesity Division, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Krista A VaradyDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA.
University of Illinois Chicago · USPennington Biomedical Research Center · US

Funding

Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Leanne Maree Redman · 2005 to 2026
$26.5M
CARDIOVASCULAR DISEASE PREVENTION TRAINING PROGRAMT32HL007034 · NHLBI · STANFORD UNIVERSITY · PI GARDNER, CHRISTOPHER D · 1985 to 2020
$8.7M
Training in Obesity ResearchT32DK064584 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI CORBY K MARTIN, Christopher D Morrison · 2003 to 2026
$5.3M
Alternate day fasting for weight loss, weight maintenance, and cardio-protectionR01HL106228 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI VARADY, KRISTA AMY · 2011 to 2014
$1.5M
Research-Reporting Fidelity within Dietary Weight-Loss Supplement Scientific LiteratureF32DK107157 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KROEGER, CYNTHIA M. · 2015 to 2017
$149k
NHLBI NIH HHS R01 HL106228NHLBI NIH HHS T32 HL007034NIDDK NIH HHS F32 DK107157NIDDK NIH HHS P30 DK072476
6 · The paper itself

Abstract

BACKGROUND &

aimsIndirect comparisons suggest that alternate-day fasting (ADF) may produce greater improvements in body composition, fat distribution, and/or the adipokine profile compared to daily calorie restriction (CR), but this has not been tested directly. In a pre-planned secondary analysis of a randomized controlled trial, we compared changes in the VAT:SAT ratio, FFM:total mass ratio, and the adipokine profile between ADF and CR.

methodsOverweight and obese participants (n = 100) were randomized to 1) ADF (alternating every 24-h between consuming 25% or 125% of energy needs); 2) CR (consuming 75% of needs every day); or 3) control (consuming 100% of needs every day) for 24 wk.

resultsThe VAT:SAT ratio did not change in any group. The FFM:total mass ratio increased in both ADF (0.03 ± 0.00) and CR (0.03 ± 0.01) compared to the control group (P < 0.01), with no differences between the intervention groups. Circulating leptin decreased in both the ADF group (-18 ± 6%) and CR group (-31 ± 10%) relative to the control group (P < 0.05), with no differences between the intervention groups. Circulating levels of adiponectin, resistin, IL-6, and TNF-α did not change in either intervention group relative to the control group.

conclusionADF and CR similarly improve the FFM:total mass ratio and reduce leptin after a 24-wk intervention.

trial registrationClinicaltrials.gov, number NCT00960505.

Indexed as

Caloric RestrictionFastingAdipokinesAdultBody CompositionBody WeightDiet, ReducingExerciseFemaleHumansLeptinMaleMiddle AgedObesityOverweightTreatment OutcomeAdipokinesLeptinAdipokineAlternate day fastingBody compositionCalorie restrictionObese adultVisceral adipose tissue

Identifiers

PMID29258678
PMCPMC5988907
OpenAlexW2774965131

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.