ArticleAlzheimer's research & therapy2017
A selenium species in cerebrospinal fluid predicts conversion to Alzheimer's dementia in persons with mild cognitive impairment.
Article in Alzheimer's research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 4 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 4 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Environmental and lifestyle risk factors for early-onset dementia: a systematic review.Acta bio-medica : Atenei Parmensis · 2022Pooled it
- Atrial Fibrillation and the Risk of Early-Onset Dementia: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2022Pooled it
- Selenium exposure and the risk of type 2 diabetes: a systematic review and meta-analysis.European journal of epidemiology · 2018Pooled it
- Selenium for preventing cancer.The Cochrane database of systematic reviews · 2018Pooled it
- Emerging Links Between Ferroptosis and Neurodegeneration: Implications for Disease Mechanisms and Nutraceutical Interventions.Food science & nutrition · 2025Review
- Changes in Cerebrospinal Fluid Concentrations of Selenium Species Induced by Tofersen Administration in Subjects with Amyotrophic Lateral Sclerosis Carrying SOD1 Gene Mutations.Biological trace element research · 2025Article
- Urinary selenium, cranial MRI, and cognitive function in American Indians: The Strong Heart Study.Environmental research · 2025Article
- Article
- The Role of Gut Microbiota in the Neuroprotective Effects of Selenium in Alzheimer's Disease.Molecular neurobiology · 2025Review
- Light at night exposure and risk of dementia conversion from mild cognitive impairment in a Northern Italy population.International journal of health geographics · 2024Article
- New horizons for the role of selenium on cognitive function: advances and challenges.Metabolic brain disease · 2024Review
- The causal effects between selenium levels and the brain cortical structure: A two-sample Mendelian randomization study.Brain and behavior · 2023Article
- Blood Selenium and Serum Glutathione Peroxidase Levels Were Associated with Serum β-Amyloid in Older Adults.Biological trace element research · 2023Article
- Article
- Hair Selenium of Residents in Keshan Disease Endemic and Non-endemic Regions in China.Biological trace element research · 2023Article
- Iron and Ferroptosis More than a Suspect: Beyond the Most Common Mechanisms of Neurodegeneration for New Therapeutic Approaches to Cognitive Decline and Dementia.International journal of molecular sciences · 2023Review
- Selenoprotein P concentrations and risk of progression from mild cognitive impairment to dementia.Scientific reports · 2023Article
- Metals in Alzheimer's Disease.Biomedicines · 2023Review
- Effect of Sodium selenite administration on the process of tendon healing in Wistar male rats.Experimental and therapeutic medicine · 2023Article
- Scientific opinion on the tolerable upper intake level for selenium.EFSA journal. European Food Safety Authority · 2023Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundLittle is known about factors influencing progression from mild cognitive impairment to Alzheimer's dementia. A potential role of environmental chemicals and specifically of selenium, a trace element of nutritional and toxicological relevance, has been suggested. Epidemiologic studies of selenium are lacking, however, with the exception of a recent randomized trial based on an organic selenium form.
methodsWe determined concentrations of selenium species in cerebrospinal fluid sampled at diagnosis in 56 participants with mild cognitive impairment of nonvascular origin. We then investigated the relation of these concentrations to subsequent conversion from mild cognitive impairment to Alzheimer's dementia.
resultsTwenty-one out of the 56 subjects developed Alzheimer's dementia during a median follow-up of 42 months; four subjects developed frontotemporal dementia and two patients Lewy body dementia. In a Cox proportional hazards model adjusting for age, sex, duration of sample storage, and education, an inorganic selenium form, selenate, showed a strong association with Alzheimer's dementia risk, with an adjusted hazard ratio of 3.1 (95% confidence interval 1.0-9.5) in subjects having a cerebrospinal fluid content above the median level, compared with those with lower concentration. The hazard ratio of Alzheimer's dementia showed little departure from unity for all other inorganic and organic selenium species. These associations were similar in analyses that measured exposure on a continuous scale, and also after excluding individuals who converted to Alzheimer's dementia at the beginning of the follow-up.
conclusionsThese results indicate that higher amounts of a potentially toxic inorganic selenium form in cerebrospinal fluid may predict conversion from mild cognitive impairment to Alzheimer's dementia.
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