ArticleArthritis research & therapy2017
Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data.
Article in Arthritis research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Predicting response to topical non-steroidal anti-inflammatory drugs in osteoarthritis: an individual patient data meta-analysis of randomized controlled trials.Rheumatology (Oxford, England) · 2020Pooled it
- Effect of Ultrasonic Penetration with Volatile Oil of Olibanum and Chuanxiong Rhizoma on Acute Knee Synovitis Induced by Sports Training: An Open-Label Randomized Controlled Study.Pain research & management · 2022Trial
- Deep learning-based effusion-synovitis volume measured on MRI is associated with osteoarthritis progression: A longitudinal analysis of data from the osteoarthritis initiative.Osteoarthritis and cartilage open · 2026Article
- Effusion and synovial hyperplasia: Distinct constructs in early and late-stage knee OA.Osteoarthritis imaging · 2026Article
- Psychological Readiness and Kinesiophobia Are Not Associated With Effusion-Synovitis in Early Recovery After Anterior Cruciate Ligament Reconstruction.Journal of sport rehabilitation · 2026Article
- Observational
- Article
- Revisiting the Subtle Relationship Between Metabolic Syndrome and Osteoarthritis.Journal of inflammation research · 2026Review
- The relationship between circulating and tissue biomarkers and OA-related pain: A systematic literature review.Osteoarthritis and cartilage open · 2025Review
- The frequency and severity of ultrasound-detected osteoarthritis features in the knees and their associations with pain: Cross-sectional analyses of the Nor-Hand study.Osteoarthritis and cartilage open · 2025Article
- Association of Synovial Innate Immune Exhaustion With Worse Pain in Knee Osteoarthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2025Article
- Imaging-based measures of synovitis in knee osteoarthritis: A scoping review and narrative synthesis.Osteoarthritis and cartilage open · 2025Review
- Obesity and hyperlipidemia were associated with more severe synovitis and structural abnormalities as well as inferior functional outcomes in knee osteoarthritis: a retrospective comparative study.Journal of orthopaedic surgery and research · 2024Article
- Inflammatory Fibroblast-Like Synoviocyte-Derived Exosomes Aggravate Osteoarthritis via Enhancing Macrophage Glycolysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Effect of Traditional Chinese Non-Pharmacological Therapies on Knee Osteoarthritis: A Narrative Review of Clinical Application and Mechanism.Orthopedic research and reviews · 2024Review
- The ultrasound assessment of osteoarthritis: the current status.Skeletal radiology · 2023Review
- Associations of Muscle Strength with Central Aspects of Pain: Data from the Knee Pain and Related Health in the Community (KPIC) Cohort.Journal of personalized medicine · 2023Article
- Concurrent Imaging and Clinical Study of the Efficacy of Hyaluronic Acid Injection for Knee Osteoarthritis: A Synovial Membrane Investigation with Ultrasound Imaging.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Synovial inflammation in osteoarthritis progression.Nature reviews. Rheumatology · 2022Review
- Effect of ultrasound-detected synovitis on therapeutic efficacy of hyaluronic acid injection for symptomatic knee osteoarthritis.Rheumatology (Oxford, England) · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAn important role for synovial pathology in the initiation and progression of knee osteoarthritis has been emphasised recently. This study aimed to examine whether ultrasonography-detected synovial changes associate with knee pain (KP) in a community population.
methodsA case-control study was conducted to compare people with early KP (n = 298), established KP (n = 100) or no KP (n = 94) at baseline. Multinomial logistic regression was used to estimate the odds ratio (OR) and 95% confidence interval (CI) between groups adjusted for radiographic osteoarthritis (ROA) severity and other confounding factors. After 1 year, 255 participants with early and established KP completed the follow-up questionnaire for changes in KP. Logistic regression with adjustment was used to determine predictors of KP worsening.
resultsAt baseline, effusion was associated with early KP (OR 2.64, 95% CI 1.57-4.45) and established KP (OR 5.07, 95% CI 2.74-9.38). Synovial hypertrophy was also associated with early KP (OR 5.43, 95% CI 2.12-13.92) and established KP (OR 13.27, 95% CI 4.97-35.43). The association with effusion diminished when adjusted for ROA. Power Doppler signal was uncommon (early KP 3%, established KP 2%, controls 0%). Baseline effusion predicted worsening of KP at 1 year (OR 1.95, 95% CI 1.05-3.64). However, after adjusting for ROA, the prediction was insignificant (adjusted OR 0.95, 95% CI 0.44-2.02).
conclusionsUltrasound effusion and synovial hypertrophy are associated with KP, but only effusion predicts KP worsening. However, the association/prediction is not independent from ROA. Power Doppler signal is uncommon in people with KP. Further study is needed to understand whether synovitis is directly involved in different types of KP.
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Registered trials
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