SynthesisTrials2017
A core outcomes set for clinical trials of interventions for young adults with type 1 diabetes: an international, multi-perspective Delphi consensus study.
Synthesis in Trials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 6 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Development of a Core Outcome Set for Studies Assessing Interventions for Diabetes-Related Foot Ulceration.Diabetes care · 2024Pooled it
- The Journey to Adulthood: A Systematic Review of Interventions in Type 1 Diabetes Paediatric to Adult Transition Care.Pediatric diabetes · 2024Pooled it
- Synthesizing Core Outcome Sets for outcomes research in cohort studies: a systematic review.Pediatric research · 2022Pooled it
- Systematic review of international Delphi surveys for core outcome set development: representation of international patients.BMJ open · 2020Pooled it
- Use of wearable biometric monitoring devices to measure outcomes in randomized clinical trials: a methodological systematic review.BMC medicine · 2020Pooled it
- Psychological interventions to improve self-management of type 1 and type 2 diabetes: a systematic review.Health technology assessment (Winchester, England) · 2020Pooled it
- Relationship between participant-reported outcomes, residual beta cell function and metabolic parameters in youth with newly diagnosed type 1 diabetes.Diabetologia · 2026Trial
- Do patients and the public understand and feel engaged and valued after reading outcome set study invitations? A UK qualitative study.BMJ open · 2026Article
- Treatment burden and health-related quality of life in young adults with type 1 diabetes.Diabetic medicine : a journal of the British Diabetic Association · 2026Article
- Psychosocial care and experiences in young adults living with early-onset type 2 diabetes: A narrative review.Diabetic medicine : a journal of the British Diabetic Association · 2026Review
- Protocol for the development of a core outcome set for type 1 diabetes risk screening.BMJ open · 2025Article
- Concept analysis of diabetes-related quality of life.Health and quality of life outcomes · 2025Review
- Regular human insulins versus rapid-acting insulin analogues in children and adolescents with type 1 diabetes: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis.Systematic reviews · 2025Article
- Use of in silico research in the development of abdominal and thoracic surgical devices: a systematic review.BMJ innovations · 2025Article
- Measuring Outcomes for Community Partner Engagement: The Case of the High-Fidelity Wraparound Program for Pediatric Type 1 Diabetes.Diabetes spectrum : a publication of the American Diabetes Association · 2025Article
- Current evidence for designing self-management support for underserved populations: an integrative review using the example of diabetes.International journal for equity in health · 2023Review
- Patient-reported outcomes for people with diabetes: what and how to measure? A narrative review.Diabetologia · 2023Review
- Identifying priority questions regarding rapid systematic reviews' methods: protocol for an eDelphi study.BMJ open · 2023Article
- Comparison of diabetes distress and depression screening results of emerging adults with type 1 diabetes onset at different ages: findings from the German early-onset T1D study and the German Diabetes Study (GDS).Diabetology & metabolic syndrome · 2023Article
- Innovative Designs and Logistical Considerations for Expedited Clinical Development of Combination Disease-Modifying Treatments for Type 1 Diabetes.Diabetes care · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 7 institutions in 5 countries.
Funding
Abstract
backgroundAchieving consensus from a range of relevant stakeholders about an agreed set of core outcomes to be measured and reported as a minimum in clinical trials has the potential to enhance evidence synthesis and make findings more relevant and applicable. Intervention research to improve outcomes for young adults with type 1 diabetes (T1DM) is hampered by inconsistent use of outcome measures. This population frequently struggles to manage their condition and reports suboptimal clinical outcomes. Our aim was to conduct an international, e-Delphi consensus study to identify a core outcome set (COS) that key stakeholders (young adults with T1DM, diabetes health professionals, diabetes researchers and diabetes policy makers) consider as essential outcomes for future intervention research.
methodsUsing a list of 87 outcomes generated from a published systematic review, we administered two online surveys to a sample of international key stakeholders. Participants in the first survey (survey 1; n = 132) and the second survey (survey 2; n = 81) rated the importance of the outcomes. Survey 2 participants received information on total mean rating for each outcome and a reminder of their personal outcome ratings from Survey 1. Survey 2 results were discussed at a consensus meeting and participants (n = 12: three young adults with T1DM, four diabetes health professionals, four diabetes researchers and one diabetes policy maker) voted on outcomes. Final core outcomes were included provided that 70% of consensus group participants voted for their inclusion.
resultsEight core outcomes were agreed for inclusion in the final COS: measures of diabetes-related stress; diabetes-related quality of life; number of severe hypoglycaemic events; self-management behaviour; number of instances of diabetic ketoacidosis (DKA); objectively measured glycated haemoglobin (HbA
conclusionsThis study is the first to identify a COS for inclusion in future intervention trials to improve outcomes for young adults with T1DM. Use of this COS will improve the quality of future research and increase opportunities for evidence synthesis. Future research is necessary to identify the most robust outcome measure instruments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.