Evidence map›Paper›PMID 29258550›Full record

ArticleJournal of translational medicine2017

The impact of antiretroviral therapy on iron homeostasis and inflammation markers in HIV-infected patients with mild anemia.

Eugenia Quiros-Roldan, Francesco Castelli, Paola Lanza, Chiara Pezzoli, Marika Vezzoli, Inflammation in HIV Study Group, Giorgio Biasiotto, Isabella Zanella

Open access · goldAbstract read
In one paragraph

Article in Journal of translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Anemia, Iron Status, and HIV: A Systematic Review of the Evidence.Advances in nutrition (Bethesda, Md.) · 2020
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Eugenia Quiros-RoldanUniversity Department of Infectious and Tropical Diseases, University of Brescia and Spedali Civili General Hospital, Brescia, Italy.
Francesco CastelliUniversity Department of Infectious and Tropical Diseases, University of Brescia and Spedali Civili General Hospital, Brescia, Italy.
Paola LanzaUniversity Department of Infectious and Tropical Diseases, University of Brescia and Spedali Civili General Hospital, Brescia, Italy.
Chiara PezzoliUniversity Department of Infectious and Tropical Diseases, Spedali Civili General Hospital, Brescia, Italy.
Marika VezzoliDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Inflammation in HIV Study Group
Giorgio BiasiottoDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Isabella ZanellaDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, Italy. isabella.zanella@unibs.it.ORCID http://orcid.org/0000-0003-3902-3376
University of Brescia · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · IT

Funding

Unconditional Grant ViiV Health Care Unconditional Grant ViiV Health CareUniversità degli Studi di Brescia ex 60%
6 · The paper itself

Abstract

backgroundAnemia is frequent during HIV infection and is predictive of mortality. Although cART has demonstrated to reduce its prevalence, several patients still experience unresolved anemia. We aimed to characterize iron homeostasis and inflammation in HIV-infected individuals with mild anemia in relation to cART.

methodsIn this retrospective cohort study, HIV-infected patients with mild anemia, CD4

resultscART improved CD4

conclusionsBaseline mild anemia in HIV-infected patients cannot always be resolved with durable efficient cART, possibly due to residual inflammation or immune activation rather than unbalanced iron homeostasis. Further research is needed on cytokine profiling to understand the mechanisms that induce anemia in HIV with suppressive cART.

Indexed as

HomeostasisAdultAnemiaAnti-HIV AgentsBiomarkersDemographyHIV InfectionsHumansInflammationIronMiddle AgedAnti-HIV AgentsBiomarkersIronAnemiacARTHepcidinHIVInflammationIron

Identifiers

PMID29258550
PMCPMC5735890
OpenAlexW2780378910

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.