Evidence map›Paper›PMID 29258539›Full record

ReviewRadiation oncology (London, England)2017

Critical appraisal of the role of volumetric modulated arc therapy in the radiation therapy management of breast cancer.

Luca Cozzi, Frank Lohr, Antonella Fogliata, Davide Franceschini, Fiorenza De Rose, A R Filippi, Gabriele Guidi, Valentina Vanoni, Marta Scorsetti

Open access · goldAbstract readReview
In one paragraph

Review in Radiation oncology (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 33 citations in OpenAlex.

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  14. Dose variability in different lymph node levels during locoregional breast cancer irradiation: the impact of deep-inspiration breath hold.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Luca CozziRadiotherapy and Radiosurgery Department, Humanitas Research Hospital, Via Manzoni 56, 20089, Rozzano-Milan, Italy. luca.cozzi@humanitas.it.ORCID http://orcid.org/0000-0001-7862-898X
Frank LohrRadiation Oncology Department, Ospedaliero-Universitaria, Modena, Italy.
Antonella FogliataRadiotherapy and Radiosurgery Department, Humanitas Research Hospital, Via Manzoni 56, 20089, Rozzano-Milan, Italy.
Davide FranceschiniRadiotherapy and Radiosurgery Department, Humanitas Research Hospital, Via Manzoni 56, 20089, Rozzano-Milan, Italy.
Fiorenza De RoseRadiotherapy and Radiosurgery Department, Humanitas Research Hospital, Via Manzoni 56, 20089, Rozzano-Milan, Italy.
A R FilippiDepartment of Radiation Oncology, Osp. S. Luigi Gonzaga University Hospital, Torino, Italy.
Gabriele GuidiMedical Physics Department, Az. Ospedaliero-Universitaria, Modena, Italy.
Valentina VanoniRadiation Oncology Department, Osp. S. Chiara, Trento, Italy.
Marta ScorsettiRadiotherapy and Radiosurgery Department, Humanitas Research Hospital, Via Manzoni 56, 20089, Rozzano-Milan, Italy.
IRCCS Humanitas Research Hospital · ITAzienda Ospedaliero-Universitaria di Modena · ITHumanitas University · ITOspedale San Luigi Gonzaga · ITOspedale Santa Chiara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this review is the critical appraisal of the current use of volumetric modulated arc therapy for the radiation therapy management of breast cancer. Both clinical and treatment planning studies were investigated. MATERIAL AND

methodsA Pubmed/MEDLINE search of the National Library of Medicine was performed to identify VMAT and breast related articles. After a first order rejection of the irrelevant findings, the remaining articles were grouped according to two main categories: clinical vs. planning studies and to some sub-categories (pointing to significant technical features). Main areas of application, dosimetric and clinical findings as well as areas of innovations were defined.

resultsA total of 131 articles were identified and of these, 67 passed a first order selection. Six studies reported clinical results while 61 treatment dealed with treatment planning investigations. Among the innovation lines, the use of high intensity photon beams (flattening filter free), altered fractionation schemes (simultaneous integrated boost, accelerated partial breast irradiation, single fraction), prone positioning and modification of standard VMAT (use of dynamic trajectories or hybrid VMAT methods) resulted among the main relevant fields of interest. Approximately 10% of the publications reported upon respiratory gating in conjunction with VMAT.

conclusionsThe role of VMAT in the radiation treatment of breast cancer seems to be consolidated in the in-silico arena while still limited evidence and only one phase II trial appeared in literature from the clinical viewpoint. More clinical reports are needed to fully proove the expected dosimetric benefits demonstrated in the planning investigations.

Indexed as

Breast NeoplasmsDisease ManagementFemaleHumansRadiotherapy DosageRadiotherapy, Intensity-ModulatedBreast cancerRadiotherapyVolumetric modulated arc therapy

Identifiers

PMID29258539
PMCPMC5735809
OpenAlexW2779433803

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.