Evidence map›Paper›PMID 29258398›Full record

ArticleBiological research for nursing2018

Pilot Study of Metabolomics and Psychoneurological Symptoms in Women With Early Stage Breast Cancer.

Debra E Lyon, Angela Starkweather, Yingwei Yao, Timothy Garrett, Debra Lynch Kelly, Victoria Menzies, Paweł Dereziński, Susmita Datta, Sreelakshmy Kumar, Colleen Jackson-Cook

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Article in Biological research for nursing, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

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  12. Tryptophan and Kynurenine Pathway Metabolites and Psychoneurological Symptoms Among Breast Cancer Survivors.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Debra E Lyon1 College of Nursing, University of Florida, Gainesville, FL, USA.
Angela Starkweather2 School of Nursing, University of Connecticut, Storrs, CT, USA.
Yingwei Yao1 College of Nursing, University of Florida, Gainesville, FL, USA.
Timothy Garrett3 Department of Pathology, Immunology and Laboratory Medicine, Southeast Center for Integrated Metabolomics, Gainesville, FL, USA.
Debra Lynch Kelly1 College of Nursing, University of Florida, Gainesville, FL, USA.
Victoria Menzies4 School of Nursing, Virginia Commonwealth University, Richmond, VA, USA.
Paweł Dereziński5 Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Poznan, Poland.
Susmita Datta6 Department of Biostatistics, College of Public Health and Health Professions, College of Medicine, University of Florida, Gainesville, FL, USA.
Sreelakshmy Kumar1 College of Nursing, University of Florida, Gainesville, FL, USA.
Colleen Jackson-Cook7 Virginia Commonwealth University, Richmond, VA, USA.
University of Florida · USVirginia Commonwealth University · USFlorida College · USJoint Center for Structural Genomics · USPoznan University of Medical Sciences · PLUniversity of Connecticut · US

Funding

Southeast Resource Center for Integrated Metabolomics (SECIM)U24DK097209 · NIDDK · UNIVERSITY OF FLORIDA · PI EDISON, ARTHUR S, YOST, RICHARD A. · 2013 to 2017
$9.2M
Epigenetics and Psychoneurologic Symptoms in Women with Breast CancerR01NR012667 · NINR · VIRGINIA COMMONWEALTH UNIVERSITY · PI JACKSON-COOK, COLLEEN K, LYON, DEBRA E · 2010 to 2014
$3.1M
Cranial Stimulation for Chemotherapy Symptoms in Breast CancerR01CA127446 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI MCGUIRE, DEBORAH B. · 2009 to 2013
$1.5M
NCI NIH HHS R01 CA127446NIDDK NIH HHS U24 DK097209NINR NIH HHS R01 NR012667
6 · The paper itself

Abstract

Many women with breast cancer experience symptoms of pain, fatigue, and depression, collectively known as psychoneurologic (PN) symptoms, during and after chemotherapy treatment. Evidence that inflammatory dysfunction related to cancer and its treatments contributes to the development and persistence of PN symptoms through several interrelated pathways is accumulating. However, a major limiting factor in more precisely identifying the biological mechanisms underlying these symptoms is the lack of biological measures that represent a holistic spectrum of biological responses. Metabolomics allows for examination of multiple, co-occurring metabolic pathways and provides a systems-level perspective on biological mechanisms that may contribute to PN symptoms.

methodsIn this pilot study, we performed serum metabolome analysis using liquid chromatography high-resolution mass spectrometry of global and targeted metabolomics from the tryptophan pathway from archived samples from 19 women with early-stage breast cancer. We used paired t tests to compare metabolite concentrations and Pearson's correlation coefficients to examine concomitant changes in metabolite concentrations and PN symptoms before and after chemotherapy.

resultsLevels of pain, fatigue, and depression increased after chemotherapy. Compared with pre-chemotherapy, global metabolites post-chemotherapy were characterized by higher concentrations of acetyl-l-alanine and indoxyl sulfate and lower levels of 5-oxo-l-proline. Targeted analysis indicated significantly higher kynurenine levels and kynurenine/tryptophan ratios post-chemotherapy. Symptoms of pain and fatigue had strong associations with multiple global and several targeted metabolites.

conclusionResults demonstrated that metabolomics may be useful for elucidating biological mechanisms associated with the development and severity of PN symptoms, specifically pain and fatigue, in women with early-stage breast cancer.

Indexed as

MetabolomicsAgedAntineoplastic AgentsBreast NeoplasmsFemaleHumansMetabolomeMiddle AgedNervous System DiseasesPilot ProjectsAntineoplastic Agentsbreast cancerchemotherapymetabolomicspsychoneurologic symptoms

Identifiers

PMID29258398
PMCPMC5873295
OpenAlexW2792149586

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.