ArticleInternational journal of molecular sciences2017
Insights into the Structural Requirements of Potent Brassinosteroids as Vegetable Growth Promoters Using Second-Internode Elongation as Biological Activity: CoMFA and CoMSIA Studies.
Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Synthesis of New Brassinosteroid 24-Norcholane Type Analogs Conjugated in C-3 with Benzoate Groups.Molecules (Basel, Switzerland) · 2021Article
- Plant Growth-Defense Trade-Offs: Molecular Processes Leading to Physiological Changes.International journal of molecular sciences · 2021Review
- Biological Activities and Molecular Docking of Brassinosteroids 24-Norcholane Type Analogs.International journal of molecular sciences · 2020Article
- Molecular Modeling and Design Studies of Purine Derivatives as Novel CDK2 Inhibitors.Molecules (Basel, Switzerland) · 2018Article
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3 authors.
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Abstract
In the present study, we have employed the ligand-based drug design technique, 3D-QSAR, through a comparative molecular field analysis (CoMFA) and a comparative molecular similarity indices analysis (CoMSIA) to determine the key factors for the plant growth promoting activity of brassinosteroids reported in literature, using the bean second-internode bioassay measured on two groups of compounds with different molar concentrations. This is the first 3D-QSAR study using the second internode elongation as biological activity. These results provide useful ideas for the design of new molecules, which could be explored in the future to identify novel vegetable growth promoters with similar or greater biological activity than natural brassinosteroids. The reliability of this study was supported by the robust statistical parameters obtained from CoMFA (Model A, r²
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