Evidence map›Paper›PMID 29258058›Full record

ReviewCurrent opinion in microbiology2018

Enterohemorrhagic Escherichia coli outwits hosts through sensing small molecules.

Kimberly M Carlson-Banning, Vanessa Sperandio

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Phytochemicals Controlling EnterohemorrhagicInternational journal of molecular sciences · 2025
    Review
  3. Molecular Aspects of the Functioning of Pathogenic Bacteria Biofilm Based onInternational journal of molecular sciences · 2024
    Review
  4. Article
  5. Article
  6. CommensalAnimals : an open access journal from MDPI · 2023
    Article
  7. Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Infant Rabbit Model for Studying Shiga Toxin-Producing Escherichia coli.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  13. Editorial: Interaction of PathogenicFrontiers in cellular and infection microbiology · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Lysosomal degradation products induceProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  18. Article
  19. Gut Microbiota-Metabolome Changes in Children With Diarrhea by DiarrheagenicFrontiers in cellular and infection microbiology · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kimberly M Carlson-BanningDepartments of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Vanessa SperandioDepartments of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: vanessa.sperandio@utsouthwestern.edu.

Funding

MOLECULAR MICROBIOLOGY TRAINING GRANTT32AI007520 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Julie K Pfeiffer · 1997 to 2026
$7.0M
Quorum sensing regulation of EHEC virulence genesR01AI053067 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SPERANDIO, VANESSA · 2003 to 2017
$6.3M
Quorum Sensing Regulation of EHEC Virulence GenesR37AI053067 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI VANESSA SPERANDIO · 2018 to 2026
$5.3M
SdiA regulation of EHEC virulenceR01AI077613 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SPERANDIO, VANESSA · 2009 to 2017
$3.4M
Tryptophan derivatives in EHEC pathogenesisR01AI114511 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SPERANDIO, VANESSA · 2015 to 2019
$2.3M
Sugar Regulation of EHEC virulenceR01AI105135 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI SPERANDIO, VANESSA · 2013 to 2016
$1.6M
NIAID NIH HHS R01 AI053067NIAID NIH HHS R01 AI077613NIAID NIH HHS R01 AI105135NIAID NIH HHS R01 AI114511NIAID NIH HHS R37 AI053067NIAID NIH HHS T32 AI007520
6 · The paper itself

Abstract

Small molecules help intestinal pathogens navigate the complex human gastrointestinal tract to exploit favorable microhabitats. These small molecules provide spatial landmarks for pathogens to regulate synthesis of virulence caches and are derived from the host, ingested plant and animal material, and the microbiota. Their concentrations and fluxes vary along the length of the gut and provide molecular signatures that are beginning to be explored through metabolomics and genetics. However, while many small molecules have been identified and are reviewed here, there are undoubtedly others that may also profoundly affect how enteric pathogens infect their hosts.

Indexed as

Host-Pathogen InteractionsAnimalsEnterohemorrhagic Escherichia coliEpinephrineEscherichia coli InfectionsEscherichia coli ProteinsEthanolamineGastrointestinal TractGene Expression Regulation, BacterialHumansMiceMicrobiotaMucinsOxygenType III Secretion SystemsVirulenceEpinephrineEscherichia coli ProteinsEthanolamineMucinsOxygenType III Secretion SystemsVirulence Factors

Identifiers

PMID29258058
PMCPMC5862742

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.