Evidence map›Paper›PMID 29258006›Full record

ArticleAtherosclerosis2018

Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A

Nina S McCarthy, Ciara Vangjeli, Praveen Surendran, Achim Treumann, Cathy Rooney, Emily Ho, Peter Sever, Simon Thom, Alun D Hughes, Patricia B Munroe and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Proteomic Markers of Dietary Patterns, CKD Progression, and Mortality in the CRIC Study.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Article
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  3. Annals of translational medicine · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 3 countries.

Nina S McCarthyMolecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, RCSI, Dublin, Ireland; Centre for the Genetic Origins of Health and Disease, University of Western Australia, Perth, Australia. Electronic address: nina.mccarthy@uwa.edu.
Ciara VangjeliMolecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, RCSI, Dublin, Ireland.
Praveen SurendranMolecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, RCSI, Dublin, Ireland; School of Medicine, UCD Conway Institute, University College Dublin, Dublin, Ireland.
Achim TreumannNewcastle University Protein and Proteome Analysis (NUPPA), University of Newcastle, Newcastle upon Tyne, UK.
Cathy RooneyMolecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, RCSI, Dublin, Ireland.
Emily HoMolecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, RCSI, Dublin, Ireland.
Peter SeverInternational Centre for Circulatory Health, Imperial College London, London, UK.
Simon ThomInternational Centre for Circulatory Health, Imperial College London, London, UK.
Alun D HughesInternational Centre for Circulatory Health, Imperial College London, London, UK.
Patricia B MunroeClinical Pharmacology, William Harvey Research Institute, Barts and the London Medical School, Queen Mary University of London and NIHR Barts Cardiovascular Biomedical Research Unit, London, UK.
Philip HowardClinical Pharmacology, William Harvey Research Institute, Barts and the London Medical School, Queen Mary University of London and NIHR Barts Cardiovascular Biomedical Research Unit, London, UK.
Toby JohnsonClinical Pharmacology, William Harvey Research Institute, Barts and the London Medical School, Queen Mary University of London and NIHR Barts Cardiovascular Biomedical Research Unit, London, UK; GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, UK.
Mark CaulfieldClinical Pharmacology, William Harvey Research Institute, Barts and the London Medical School, Queen Mary University of London and NIHR Barts Cardiovascular Biomedical Research Unit, London, UK.
Denis C ShieldsSchool of Medicine, UCD Conway Institute, University College Dublin, Dublin, Ireland.
Eoin O'BrienSchool of Medicine, UCD Conway Institute, University College Dublin, Dublin, Ireland.
Desmond J FitzgeraldSchool of Medicine, UCD Conway Institute, University College Dublin, Dublin, Ireland.
Alice V StantonMolecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, RCSI, Dublin, Ireland.
Royal College of Surgeons in Ireland · IEImperial College London · GBUniversity College Dublin · IEWilliam Harvey Research Institute · GBNewcastle University · GBQueen Mary University of London · GB

Funding

British Heart Foundation CS/15/6/31468British Heart Foundation RG/08/014/24067Medical Research Council G0600237Medical Research Council G9521010Medical Research Council MR/K006584/1Medical Research Council MR/L003120/1
6 · The paper itself

Abstract

BACKGROUND AND

aimsElevated urinary 11-dehydro thromboxane B

methodsGenome-wide and targeted genetic association studies of urinary 11-dehydro TxB

resultsThe strongest associations were in PPARGC1B (rs4235745, rs32582, rs10515638) and CNTN4 (rs10510230, rs4684343), these 5 single nucleotide polymorphisms (SNPs) were independently associated with 11-dehydro TxB

conclusionsPPARGC1B and CNTN4 genotypes are associated with elevated thromboxane A

Indexed as

Polymorphism, Single NucleotideAgedAspirinCardiovascular AgentsCardiovascular DiseasesCarrier ProteinsContactinsEuropeFemaleGene FrequencyGenetic MarkersGenetic Predisposition to DiseaseGenome-Wide Association StudyHaplotypesHumansIncidence11-dehydro-thromboxane B2AspirinCardiovascular AgentsCarrier ProteinsCNTN4 protein, humanContactinsGenetic MarkersPPARGC1B protein, humanRNA-Binding ProteinsThromboxane A2Thromboxane B2Genome wide association studyThrombosisThromboxane

Identifiers

PMID29258006
PMCPMC5813793
OpenAlexW2772639291

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.