Evidence map›Paper›PMID 29257865›Full record

ReviewACS nano2018

Nanotechnology Strategies To Advance Outcomes in Clinical Cancer Care.

Christopher M Hartshorn, Michelle S Bradbury, Gregory M Lanza, Andre E Nel, Jianghong Rao, Andrew Z Wang, Ulrich B Wiesner, Lily Yang, Piotr Grodzinski

Abstract readReview
In one paragraph

Review in ACS nano, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Evaluation ofACS omega · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Nano-Based Technology in Glioblastoma.Molecules (Basel, Switzerland) · 2025
    Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Recent Insights into Nanotechnology in Colorectal Cancer.Applied biochemistry and biotechnology · 2024
    Review
  18. Review
  19. Review
  20. Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christopher M HartshornNational Cancer Institute, National Institutes of Health , Bethesda, Maryland 20892, United States.ORCID 0000-0002-9978-6394
Michelle S BradburyDepartment of Radiology and Molecular Pharmacology Program, Sloan Kettering Institute for Cancer Research , New York, New York 10065, United States.ORCID 0000-0003-3147-4391
Gregory M LanzaDepartment of Medicine, Washington University School of Medicine , Saint Louis, Missouri 63108, United States.
Andre E NelDivision of NanoMedicine, Department of Medicine, and California NanoSystems Institute, University of California , Los Angeles, California 90095, United States.ORCID 0000-0002-5232-4686
Jianghong RaoDepartment of Radiology and Molecular Imaging Program at Stanford (MIPS), Stanford School of Medicine , Stanford, California 94305, United States.
Andrew Z WangLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
Ulrich B WiesnerDepartment of Materials Science and Engineering, Cornell University , Ithaca, New York 14843, United States.ORCID 0000-0001-6934-3755
Lily YangDepartment of Surgery, Emory University School of Medicine , Atlanta, Georgia 30322, United States.
Piotr GrodzinskiNational Cancer Institute, National Institutes of Health , Bethesda, Maryland 20892, United States.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Small Animal Imaging CoreU54CA198999 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, ZIBO · 2015 to 2019
$11.9M
Project 2 - Radiation-Induced Treatment of Multiple Myeloma using NanoparticlesU54CA199092 · NCI · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2015 to 2019
$11.5M
Nano Characterization and Nano Fabrication CoreU54CA199075 · NCI · STANFORD UNIVERSITY · PI GAMBHIR, SANJIV S · 2015 to 2019
$9.6M
Real-time Intraoperative Imaging of Cancer Biomarkers and Peripheral NervesU54CA199081 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S. · 2015 to 2019
$8.3M
Stroma Breaking Theranostic Nanoparticle for Targeted Pancreatic Cancer TherapyU01CA198913 · NCI · EMORY UNIVERSITY · PI MAO, HUI, YANG, LILY · 2015 to 2019
$3.0M
UCLA Multifunctional Mesoporous Silica Nanoparticle Platform for Treatment of Pancreas CancerU01CA198846 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DONAHUE, TIMOTHY R, MENG, HUAN · 2015 to 2019
$2.4M
Intramural NIH HHS Z99 CA999999NCI NIH HHS P30 CA008748NCI NIH HHS U01 CA198846NCI NIH HHS U01 CA198913NCI NIH HHS U54 CA198999NCI NIH HHS U54 CA199075NCI NIH HHS U54 CA199081NCI NIH HHS U54 CA199092
6 · The paper itself

Abstract

Ongoing research into the application of nanotechnology for cancer treatment and diagnosis has demonstrated its advantages within contemporary oncology as well as its intrinsic limitations. The National Cancer Institute publishes the Cancer Nanotechnology Plan every 5 years since 2005. The most recent iteration helped codify the ongoing basic and translational efforts of the field and displayed its breadth with several evolving areas. From merely a technological perspective, this field has seen tremendous growth and success. However, an incomplete understanding of human cancer biology persists relative to the application of nanoscale materials within contemporary oncology. As such, this review presents several evolving areas in cancer nanotechnology in order to identify key clinical and biological challenges that need to be addressed to improve patient outcomes. From this clinical perspective, a sampling of the nano-enabled solutions attempting to overcome barriers faced by traditional therapeutics and diagnostics in the clinical setting are discussed. Finally, a strategic outlook of the future is discussed to highlight the need for next-generation cancer nanotechnology tools designed to address critical gaps in clinical cancer care.

Indexed as

AnimalsHumansImmunotherapyNanomedicineNanotechnologyNational Cancer Institute (U.S.)Neoplasm MetastasisNeoplasmsSurgery, Computer-AssistedTreatment OutcomeUnited Statesalliancebiological barrierscancerCancer Nanotechnology Planimage-guided surgeryimmunotherapymetastasisnanotechnologyNational Cancer Instituteoncologyradiotherapy

Identifiers

PMID29257865
PMCPMC6589353

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.