Evidence map›Paper›PMID 29257842›Full record

ArticleArquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery

IMMUNOMODULATING EFFECTS OF THE PURIFIED HEV B 13 FRACTION ON SEPTIC RATS.

Maxley Martins Alves, Lilhian Alves de Araújo, Fátima Mrué, Clayson Moura Gomes, Milton Adriano Pelli de Oliveira, Roberpaulo Anacleto Neves, Nelson Jorge da Silva-Júnior, Paulo Roberto de Melo-Reis

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. EFFECTS OF INTRAPERITONEAL GLUTAMINE IN THE TREATMENT OF EXPERIMENTAL SEPSIS.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Maxley Martins AlvesLaboratory of Experimental and Biotechnological Studies of the Post-Graduate Program in Environmental Sciences and Health, Area V, Campus I, Pontifical Catholic University of Goiás.
Lilhian Alves de AraújoLaboratory of Experimental and Biotechnological Studies of the Post-Graduate Program in Environmental Sciences and Health, Area V, Campus I, Pontifical Catholic University of Goiás.
Fátima MruéLaboratory of Experimental and Biotechnological Studies of the Post-Graduate Program in Environmental Sciences and Health, Area V, Campus I, Pontifical Catholic University of Goiás.
Clayson Moura GomesLaboratory of Experimental and Biotechnological Studies of the Post-Graduate Program in Environmental Sciences and Health, Area V, Campus I, Pontifical Catholic University of Goiás.
Milton Adriano Pelli de OliveiraLaboratory of Cytokines, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, Brazil.
Roberpaulo Anacleto NevesLaboratory of Experimental and Biotechnological Studies of the Post-Graduate Program in Environmental Sciences and Health, Area V, Campus I, Pontifical Catholic University of Goiás.
Nelson Jorge da Silva-JúniorLaboratory of Experimental and Biotechnological Studies of the Post-Graduate Program in Environmental Sciences and Health, Area V, Campus I, Pontifical Catholic University of Goiás.
Paulo Roberto de Melo-ReisLaboratory of Experimental and Biotechnological Studies of the Post-Graduate Program in Environmental Sciences and Health, Area V, Campus I, Pontifical Catholic University of Goiás.
Pontifícia Universidade Católica de Goiás · BRUniversidade Federal de Goiás · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSepsis is a potentially life-threatening complication of an infection that occurs when chemicals released into the bloodstream to fight the infection trigger inflammatory responses throughout the body, especially in the acute phase of the disease, producing excessive pro-inflammatory cytokines, leading to multiple organ injury and death. The Hev b 13 fraction has demonstrated biological activity capable of inducing IL-10 production and shrinking inflammatory disease lesions.

aimTo investigate the immunomodulating effects of the Hev b 13 fraction on septic rats.

methodsAcinetobacter baumannii was injected into the peritoneal cavity of the animals after sustaining a lesion in the pancreas, with the stomach as an entry point. After 10 h of infection, they were euthanized for blood and lung collection, followed by total and differential leukocyte count, determination of cytokine level and histopathological analysis.

resultsAdministering a single dose of the Hev b 13 fraction 2 h after sepsis induction significantly decreased total leukocyte count. Higher IL-10 and IL-4 and lower IL-6 production shrank the lung tissue lesions compared to the control groups.

conclusionThe Hev b 13 fraction exhibits an anti-inflammatory tendency, with potential for sepsis treatment.

Indexed as

ImmunomodulationPhytotherapyAnimalsAntigens, PlantMalePlant ProteinsRatsRats, WistarSepsisAntigens, PlantHev b 13 allergen, Hevea brasiliensisPlant Proteins

Identifiers

PMID29257842
PMCPMC5543785
OpenAlexW2740800275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.