ArticleMolecular medicine reports2018
A cellular spinal cord scaffold seeded with rat adipose‑derived stem cells facilitates functional recovery via enhancing axon regeneration in spinal cord injured rats.
Article in Molecular medicine reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The trial behind it
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Research Progress on Biomaterials for Spinal Cord Repair.International journal of nanomedicine · 2025Review
- Injectable alginate chitosan hydrogel as a promising bioengineered therapy for acute spinal cord injury.Scientific reports · 2024Article
- The Application of Biomaterials in Spinal Cord Injury.International journal of molecular sciences · 2023Review
- Pathophysiology of Spinal Cord Injury and Tissue Engineering Approach for Its Neuronal Regeneration: Current Status and Future Prospects.Advances in experimental medicine and biology · 2023Review
- Effects of Resistance Training on Oxidative Stress Markers and Muscle Damage in Spinal Cord Injured Rats.Biology · 2021Article
- Decellularization of Nervous Tissues and Clinical Application.Advances in experimental medicine and biology · 2021Article
- Combating COVID-19 with tissue engineering: a review.Emergent materials · 2021Review
- Serine Proteases and Chemokines in Neurotrauma: New Targets for Immune Modulating Therapeutics in Spinal Cord Injury.Current neuropharmacology · 2021Review
- Adipose-Derived Stem Cells: Current Applications and Future Directions in the Regeneration of Multiple Tissues.Stem cells international · 2020Review
- Fate of systemically and locally administered adipose-derived mesenchymal stromal cells and their effect on wound healing.Stem cells translational medicine · 2020Article
- Role and prospects of regenerative biomaterials in the repair of spinal cord injury.Neural regeneration research · 2019Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinal cord injury (SCI), usually resulting in severe sensory and motor deficits, is a major public health concern. Adipose‑derived stem cells (ADSCs), one type of adult stem cell, are free from ethical restriction, easily isolated and enriched. Therefore, ADSCs may provide a feasible cell source for cell‑based therapies in treatment of SCI. The present study successfully isolated rat ADSCs (rADSCs) from Sprague‑Dawley male rats and co‑cultured them with acellular spinal cord scaffolds (ASCs). Then, a rat spinal cord hemisection model was built and rats were randomly divided into 3 groups: SCI only, ASC only, and ASC + ADSCs. Furthermore, behavioral tests were conducted to evaluate functional recovery. Hematoxylin & Eosin staining and immunofluorence were carried out to assess histopathological remodeling. In addition, biotinylated dextran amines anterograde tracing was employed to visualize axon regeneration. The data demonstrated that harvested cells, which were positive for cell surface antigen cluster of differentiation (CD) 29, CD44 and CD90 and negative for CD4, detected by flow cytometry analysis, held the potential to differentiate into osteocytes and adipocytes. Rats that received transplantation of ASCs seeded with rADSCs benefited greatly in functional recovery through facilitation of histopathological rehabilitation, axon regeneration and reduction of reactive gliosis. rADSCs co‑cultured with ASCs may survive and integrate into the host spinal cord on day 14 post‑SCI.
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Registered trials
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