ArticleMolecular medicine reports2018
MicroRNA‑376a inhibits cell proliferation and invasion in glioblastoma multiforme by directly targeting specificity protein 1.
Article in Molecular medicine reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Diagnostic Potential of Circulating miRNAs in Glioma: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2026Pooled it
- Development of microRNA-Based Glioblastoma Biomarkers Using Blood Plasma Specimens.Diagnostics (Basel, Switzerland) · 2026Article
- miR-3613-5p promotes lung cancer progression by targeting and regulating XPO6.Discover oncology · 2025Article
- Combinatorial phenethyl isothiocyanate and withaferin A targets multiple epigenetics pathways to inhibit MCF-7 and MDA-MB-231 human breast cancer cells.Cancer cell international · 2024Article
- MiR-376a-3p increases cell apoptosis in acute myeloid leukemia by targeting MT1X.Cancer biology & therapy · 2022Article
- Non-coding RNAs and glioblastoma: Insight into their roles in metastasis.Molecular therapy oncolytics · 2022Review
- MicroRNA Alterations Induced in Human Skin by Diesel Fumes, Ozone, and UV Radiation.Journal of personalized medicine · 2022Article
- Long Noncoding RNA WEE2-AS1 Plays an Oncogenic Role in Glioblastoma by Functioning as a Molecular Sponge for MicroRNA-520f-3p.Oncology research · 2021Article
- Strategies to Modulate MicroRNA Functions for the Treatment of Cancer or Organ Injury.Pharmacological reviews · 2020Review
- miR-376a inhibits the proliferation and invasion of osteosarcoma by targeting FBXO11.Human cell · 2019Article
- lncRNA MNX1-AS1 Promotes Glioblastoma Progression Through Inhibition of miR-4443.Oncology research · 2019Article
- MiRNA-130a-3p inhibits cell proliferation, migration, and TMZ resistance in glioblastoma by targeting Sp1.American journal of translational research · 2019Article
- MicroRNA-382 inhibits cell growth and migration in colorectal cancer by targeting SP1.Biological research · 2018Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glioblastoma multiforme (GBM), a World Health Organization grade IV glioma, is the most common and aggressive primary brain tumor in humans. microRNAs (miRNAs) are aberrantly expressed in numerous cancer types, including GBM. Abnormally expressed miRNAs are commonly associated with malignant characteristics of GBM, including malignant growth, proliferation, apoptosis, invasion, metastasis and resistance to chemotherapy. miRNA (miR)‑376a is abnormally expressed in multiple human cancers; however, the expression pattern and role of miR‑376a in GBM, and the underlying molecular mechanisms by which miR‑376a exerts its functions remain to be elucidated. Therefore, the aim of this study was to measure miR‑376a expression and determine its biological roles in GBM as well as its associated molecular mechanism. In the present study, miR‑376a expression was markedly downregulated in GBM tissues and cell lines. Overexpression of miR‑376a markedly decreased the proliferation and invasion of GBM cells in vitro. In the present study, specificity protein 1 (SP1) was demonstrated to be a direct target of miR‑376a. In addition, a negative association between SP1 mRNA and miR‑376a expression was observed in GBM tissues. SP1 upregulation reduced the effects of miR‑376a overexpression on GBM cell proliferation and invasion. miR‑376a may be a therapeutic target for the treatment of patients with GBM.
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Registered trials
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