Evidence map›Paper›PMID 29257140›Full record

Trial reportThe American journal of gastroenterology2018

Effects of Antidepressants on Gastric Function in Patients with Functional Dyspepsia.

B E Lacy, Y A Saito, M Camilleri, E Bouras, J K DiBaise, L M Herrick, L A Szarka, K Tilkes, A R Zinsmeister, N J Talley

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in The American journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 71 citations in OpenAlex.

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  20. Associations of gastric volumes, ingestive behavior, calorie and volume intake, and fullness in obesity.American journal of physiology. Gastrointestinal and liver physiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

B E LacyGastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
Y A SaitoGastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
M CamilleriGastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
E BourasGastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA.
J K DiBaiseGastroenterology and Hepatology, Mayo Clinic, Scottsdale, Arizona, USA.
L M HerrickGastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
L A SzarkaGastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
K TilkesGastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
A R ZinsmeisterBiomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA.
N J TalleyFaculty of Health and Medicine, University of Newcastle, Callaghan, New South Wales, Australia.
Mayo Clinic · USWinnMed · USDartmouth–Hitchcock Medical Center · USJacksonville College · USMayo Clinic in Arizona · USUniversity of Newcastle Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFunctional dyspepsia (FD) is a highly prevalent functional bowel disorder. The effects of antidepressant therapy (ADTx) on gastric sensorimotor function in FD patients are poorly understood.

aimsDetermine whether FD and subtypes with abnormalities in gastric function respond differently to ADTx compared to those with normal physiology.

methodsThis multicenter, prospective trial randomized FD patients to 12 weeks of amitriptyline (AMI; 50 mg), escitalopram (ESC; 10 mg), or matching placebo. Demographics, symptoms, psychological distress, gastric emptying, and satiation were measured. Gastric accommodation (GA) using single-photon emission computed tomography imaging was performed in a subset of patients. An intent to treat analysis included all randomized subjects. The effect of treatment on gastric emptying was assessed using ANCOVA. A post hoc appraisal of the data was performed categorizing patients according to the Rome III subgrouping (PDS and EPS).

resultsIn total, 292 subjects were randomized; mean age=44 yrs. 21% had delayed gastric emptying. Neither antidepressant altered gastric emptying, even in those with baseline delayed gastric emptying. GA increased with ADTx (P=0.02). Neither antidepressant affected the maximal-tolerated volume (MTV) of the nutrient drink test although aggregate symptom scores improved compared to placebo (P=0.04). Patients with the combined EPS-PDS subtype (48%) had a lower MTV on the nutrient drink test compared to the EPS group at baseline (P=0.02). Postprandial bloating improved with both AMI (P=0.03) and ESC (P=0.02).

conclusionsAmitriptyline (50 mg) improves FD symptoms but does not delay gastric emptying, even in patients with baseline delayed gastric emptying. GA improved with low-dose ADTx; the precise mechanism of action is unknown warranting further study.

Indexed as

Gastric EmptyingSatiationAdultAmitriptylineAntidepressive AgentsCitalopramDyspepsiaFemaleGastroparesisHumansMaleMiddle AgedPostprandial PeriodStress, PsychologicalTomography, Emission-Computed, Single-PhotonAmitriptylineAntidepressive AgentsCitalopram

Identifiers

PMID29257140
OpenAlexW2780734183

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.