Evidence map›Paper›PMID 29257087›Full record

ArticleInternational journal of molecular sciences2017

Microsomal Prostaglandin E Synthase-1 Facilitates an Intercellular Interaction between CD4⁺ T Cells through IL-1β Autocrine Function in Experimental Autoimmune Encephalomyelitis.

Takako Takemiya, Chisen Takeuchi, Marumi Kawakami

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Advances in Multiple Sclerosis 2017.International journal of molecular sciences · 2018
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Takako TakemiyaMedical Research Institute, Tokyo Women's Medical University, Tokyo 162-8666, Japan. takemiya.takako@twmu.ac.jp.ORCID 0000-0003-0877-5698
Chisen TakeuchiDepartment of Neurology, Tokyo Metropolitan Kita Medical and Rehabilitation Center for the Disabled, Tokyo 114-0033, Japan. chisentakeuchi@gmail.com.
Marumi KawakamiMedical Research Institute, Tokyo Women's Medical University, Tokyo 162-8666, Japan. kawakami.marumi@twmu.ac.jp.
Tokyo Women's Medical University · JPTokyo-Kita Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microsomal prostaglandin synthetase-1 (mPGES-1) is an inducible terminal enzyme that produces prostaglandin E₂ (PGE₂). In our previous study, we investigated the role of mPGES-1 in the inflammation and demyelination observed in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, using

Indexed as

Autocrine CommunicationAnimalsCD4-Positive T-LymphocytesEncephalomyelitis, Autoimmune, ExperimentalFemaleInterleukin-1betaMiceMice, Inbred C57BLMyelin SheathProstaglandin-E SynthasesReceptors, Interleukin-1 Type IIL1R1 protein, mouseInterleukin-1betaProstaglandin-E SynthasesPtges protein, mouseReceptors, Interleukin-1 Type ICD4-positive T cells (CD4+ T cells)experimental allergic encephalomyelitis (EAE)interleukin-17 (IL-17)interleukin-1β (IL-1β)microsomal prostaglandin synthetase-1 (mPGES-1)mPGES-1-deficient (mPGES-1−/−) micemultiple sclerosis (MS)myelin oligodendrocyte glycoprotein35–55 peptide (MOG35–55)prostaglandin E2 (PGE2)vascular endothelial cells (VECs)

Identifiers

PMID29257087
PMCPMC5751357
OpenAlexW2778825179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.