Evidence map›Paper›PMID 29256864›Full record

ArticleeLife2017

Mechanistic insights into the active site and allosteric communication pathways in human nonmuscle myosin-2C.

Krishna Chinthalapudi, Sarah M Heissler, Matthias Preller, James R Sellers, Dietmar J Manstein

Abstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Structure, regulation, and mechanisms of nonmuscle myosin-2.Cellular and molecular life sciences : CMLS · 2024
    Review
  3. Article
  4. Review
  5. Review
  6. Alpha and beta myosin isoforms and human atrial and ventricular contraction.Cellular and molecular life sciences : CMLS · 2021
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. 4-Hydroxyacetophenone modulates the actomyosin cytoskeleton to reduce metastasis.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Structural and mechanistic insights into the function of the unconventional class XIV myosin MyoA fromProceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Krishna Chinthalapudi *Institute for Biophysical Chemistry, OE4350, Hannover Medical School, Hannover, Germany.
Sarah M Heissler *Institute for Biophysical Chemistry, OE4350, Hannover Medical School, Hannover, Germany.
Matthias PrellerInstitute for Biophysical Chemistry, OE4350, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0002-7784-4012
James R SellersLaboratory of Molecular Physiology, NHLBI, National Institutes of Health, Bethesda, United States.ORCID https://orcid.org/0000-0001-6296-564X
Dietmar J MansteinInstitute for Biophysical Chemistry, OE4350, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0003-0763-0147

Funding

Regulation Of Smooth and Nonmuscle MyosinZIAHL001786 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SELLERS, JAMES · 2009 to 2025
$17.4M
6 · The paper itself

Abstract

Despite a generic, highly conserved motor domain, ATP turnover kinetics and their activation by F-actin vary greatly between myosin-2 isoforms. Here, we present a 2.25 Å pre-powerstroke state (ADP⋅VO

Indexed as

Catalytic DomainAdenosine TriphosphateAllosteric RegulationCrystallography, X-RayDNA Mutational AnalysisHumansKineticsModels, MolecularMolecular Dynamics SimulationMyosin Type IIProtein ConformationAdenosine TriphosphateMyosin Type IIactinallosteryArgopecten irradiansbiophysicschickencytoskeletondictyosteliumE. colihumanmyosinSpodoptera frugiperdastructural biology

Identifiers

PMID29256864
PMCPMC5749951

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.