ArticleNature chemistry2018
Designing cooperatively folded abiotic uni- and multimolecular helix bundles.
Article in Nature chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Helical Folding of Abiotic Chiral Poly(phosphodiester)s.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Chalcogen bonding-directed photoresponsive helix from azo-fused H-bonded arylamide foldamers.Chemical science · 2026Article
- Gold clusters assembled homochiral helical microbowties.Science advances · 2025Article
- Supramolecular rosette intermediated homochiral double helix.Nature communications · 2025Article
- Design of an abiotic unimolecular three-helix bundle.Chemical science · 2025Article
- Exo-chirality of the α-helix.Nature communications · 2024Article
- Article
- Controlling aromatic helix dimerization in water by tuning charge repulsions.Chemical science · 2023Article
- Unnatural helical peptidic foldamers as protein segment mimics.Chemical Society reviews · 2023Review
- An abiotic, tetrameric, eight-helix bundle.Chemical science · 2023Article
- Hierarchically self-assembled homochiral helical microtoroids.Nature nanotechnology · 2022Article
- Directing the Self-Assembly of Aromatic Foldamer Helices using Acridine Appendages and Metal Coordination.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Discrete Stacked Dimers of Aromatic Oligoamide Helices.Angewandte Chemie (International ed. in English) · 2022Article
- Loading Linear Arrays of CuAngewandte Chemie (International ed. in English) · 2021Article
- A versatile living polymerization method for aromatic amides.Nature chemistry · 2021Article
- Hierarchical communication of chirality for aromatic oligoamide sequences.Nature communications · 2021Article
- Applications of Discrete Synthetic Macromolecules in Life and Materials Science: Recent and Future Trends.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Large-Amplitude Conformational Changes in Self-Assembled Multi-Stranded Aromatic Sheets.Angewandte Chemie (International ed. in English) · 2021Article
- Analysis of folded structure and folding thermodynamics in heterogeneous-backbone proteomimetics.Methods in enzymology · 2021Review
- Effects of turn-structure on folding and entanglement in artificial molecular overhand knots.Chemical science · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abiotic foldamers, that is foldamers that have backbones chemically remote from peptidic and nucleotidic skeletons, may give access to shapes and functions different to those of peptides and nucleotides. However, design methodologies towards abiotic tertiary and quaternary structures are yet to be developed. Here we report rationally designed interactional patterns to guide the folding and assembly of abiotic helix bundles. Computational design facilitated the introduction of hydrogen-bonding functionalities at defined locations on the aromatic amide backbones that promote cooperative folding into helix-turn-helix motifs in organic solvents. The hydrogen-bond-directed aggregation of helices not linked by a turn unit produced several thermodynamically and kinetically stable homochiral dimeric and trimeric bundles with structures that are distinct from the designed helix-turn-helix. Relative helix orientation within the bundles may be changed from parallel to tilted on subtle solvent variations. Altogether, these results prefigure the richness and uniqueness of abiotic tertiary structure behaviour.
Identifiers
29256508What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.