ArticleJournal of fluorescence2018
Human Saliva for Oral Precancer Detection: a Comparison of Fluorescence & Stokes Shift Spectroscopy.
Article in Journal of fluorescence, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Detection of Stages of Oral Cavity Lesions Using a Fluorescence Portable Device and Their Classification by Artificial Intelligence Tools.Asian Pacific journal of cancer prevention : APJCP · 2026Article
- Spatial metabolomics atlas in the progression of oral squamous cell carcinoma.Journal of translational medicine · 2025Article
- Integration of the fluorescence based portable device with the AI tools for the real-time monitoring of oral mucosal lesions.Scientific reports · 2025Article
- Salivary biomarkers for early detection of oral squamous cell carcinoma (OSCC) and head/neck squamous cell carcinoma (HNSCC): A systematic review and network meta-analysis.The Japanese dental science review · 2024Review
- Detection of oral mucosal lesions by the fluorescence spectroscopy and classification of cancerous stages by support vector machine.Lasers in medical science · 2024Article
- Human Saliva as a Substitute Diagnostic Medium for the Detection of Oral Lesions Using the Stokes Shift Spectroscopy: Discrimination among the Groups by Multivariate Analysis Methods.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- In-vivo Testing of Oral Mucosal Lesions with an In-house Developed Portable Imaging Device and Comparison with Spectroscopy Results.Journal of fluorescence · 2023Article
- Specific fluorescent signatures for body fluid identification using fluorescence spectroscopy.Scientific reports · 2023Article
- Design, fabrication and testing of 3D printed smartphone-based device for collection of intrinsic fluorescence from human cervix.Scientific reports · 2022Article
- Photonics of human saliva: potential optical methods for the screening of abnormal health conditions and infections.Biophysical reviews · 2021Review
- Differences in Spectroscopic Properties of Saliva Taken From Normal Subjects and Oral Cancer Patients: Comparison Studies.Journal of fluorescence · 2021Article
- In vivo detection of oral precancer using a fluorescence-based, in-house-fabricated device: a Mahalanobis distance-based classification.Lasers in medical science · 2019Article
- Concentration of FAD as a marker for cervical precancer detection.Journal of biomedical optics · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report here a study on human saliva tested as a diagnostic medium for oral cancer detection on three groups: oral squamous cell carcinoma (OSCC), oral sub mucous fibrosis (OSMF; precancer), and healthy controls (normal). Measurements have been conducted using fluorescence spectroscopy with 350 nm excitation and Stokes shift (SS) spectroscopy (SSS) with 120 nm shift from a total of 99 saliva samples. For classification, principal component analysis (PCA) and linear discriminant analysis (LDA) have been applied on the data sets. Linear discriminant (LD) scores of fluorescence spectra are able to differentiate OSCC to normal, OSMF to normal and OSCC to OSMF with sensitivities 91%, 92%, 91% and specificities 97%, 100%, 94% respectively, while LD scores of SS spectra differentiate respective groups with sensitivities 100%, 94%, 94% and specificities 97%, 100%, 94%. Cross-validation on the datasets of PC scores during LDA illustrates that sensitivity and specificity of SSS data are less affected than those of fluorescence data. Saliva is thus seen as a potential non-invasive and simple diagnostic medium, with SS spectroscopy as a better diagnostic tool for oral precancer.
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