SynthesisCNS drugs2017
Effectiveness of Pharmacological Treatment for Attention-Deficit/Hyperactivity Disorder on Physical Injuries: A Systematic Review and Meta-Analysis of Observational Studies.
Synthesis in CNS drugs, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Risks and Benefits of Attention-Deficit/Hyperactivity Disorder Medication on Behavioral and Neuropsychiatric Outcomes: A Qualitative Review of Pharmacoepidemiology Studies Using Linked Prescription Databases.Biological psychiatry · 2019Pooled it
- Impulsivity and inattention in hand tendon injuries: a case-control study revealing distinct profiles for work-related accidents.Archives of orthopaedic and trauma surgery · 2026Observational
- Effect of ADHD medication on risk of injuries: a preference-based instrumental variable analysis.European child & adolescent psychiatry · 2024Article
- ADHD medications use and risk of mortality and unintentional injuries: a population-based cohort study.Translational psychiatry · 2024Article
- A systematic meta-review of systematic reviews on attention deficit hyperactivity disorder.European psychiatry : the journal of the Association of European Psychiatrists · 2023Review
- Increased fracture risk among children diagnosed with attention- deficit/hyperactivity disorder: a large matched cohort study.European journal of pediatrics · 2023Article
- Methylphenidate and TBI in ADHD and co-occurring epilepsy and mental disorders: a self-controlled case series study.European child & adolescent psychiatry · 2022Article
- Article
- Methylphenidate Use and Infectious Diseases in Children With Attention Deficit and Hyperactivity Disorder: A Population-Based Study.Frontiers in medicine · 2021Article
- Attention-Deficit/Hyperactivity Disorder Medication and Unintentional Injuries in Children and Adolescents.Journal of the American Academy of Child and Adolescent Psychiatry · 2020Article
- [Pharmacotherapy of attention deficit hyperactivity disorder in adults].Der Nervenarzt · 2020Review
- Prevalence of ADHD in Accident Victims: Results of the PRADA Study.Journal of clinical medicine · 2019Article
- Attention-Deficit/Hyperactivity Disorder and Mortality Risk in Taiwan.JAMA network open · 2019Article
- Prevalence of Attention Deficit Hyperactivity Disorder Symptoms in Children Who Were Treated at Emergency Service due to Unintentional Injury.Emergency medicine international · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with attention-deficit/hyperactivity disorder (ADHD) are more prone to physical injuries, including motor vehicle accidents, fractures and brain injuries. Several observational studies have been published investigating the association between the use of pharmacological treatment for ADHD and the incidence of physical injuries among patients with ADHD; however, the findings are not concordant.
objectiveThis study is a systematic review and meta-analysis of the existing literature and estimates the overall association between the use of ADHD medications and physical injury. Injury is defined as medically attended physical injuries in the form of hospitalisations, emergency department visits or general practitioners visits.
methodsThe PubMed, EMBASE, PsycINFO, CINAHL and Cochrane Review databases were searched for relevant studies published up to May 2017 relating to ADHD medication and risk of injuries. Observational studies with any study design, all age groups (children and adults) and all ADHD medications (stimulant and non-stimulants) were included. Studies relevant to the association between ADHD medication exposure and risk of injuries in ADHD patients were extracted and compiled for meta-analysis. Both within-individual and between-individual analyses were conducted.
resultsOverall, 2001 citations were identified and 10 observational studies were included. Three self-controlled case series and two self-controlled cohorts were eligible for meta-analysis of within-individual studies. Five cohort studies were included in the meta-analysis of between-individual studies. The adjusted rate ratio of the within-individual methods was 0.76 (95% confidence interval [CI] 0.61-0.93) and 0.88 (95% CI 0.85-0.92) for between-individual studies.
conclusionThe findings of this meta-analysis support a reduced risk of injuries among ADHD patients who were treated with ADHD medications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.