ArticleJournal of industrial microbiology & biotechnology2018
Discovery of a new diol-containing polyketide by heterologous expression of a silent biosynthetic gene cluster from Streptomyces lavendulae FRI-5.
Article in Journal of industrial microbiology & biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Draft genome sequence ofMicrobiology resource announcements · 2026Article
- Droplet based microfluidic and miniaturization at high-throughput level to screening heterologous secondary metabolites in microbes: A critical review.Biotechnology letters · 2025Review
- Expanding catalytic versatility of modular polyketide synthases for alcohol biosynthesis.Nature chemical biology · 2025Article
- Discovery of Streptomyces marinisediminis sp. nov., a new thiolutin producing actinomycete isolated from Thai marine sediment.Scientific reports · 2025Article
- Identification of a critical gene involved in the biosynthesis of the polyene macrolide lavencidin inApplied and environmental microbiology · 2025Article
- Article
- Multi-omics Data Reveal the Effect of Sodium Butyrate on Gene Expression and Protein Modification in Streptomyces.Genomics, proteomics & bioinformatics · 2023Article
- Metabolic engineering ofEngineering microbiology · 2022Review
- Lavencidin, a polyene macrolide antibiotic from Streptomyces lavendulae FRI-5.The Journal of antibiotics · 2021Article
- Desert Environments Facilitate Unique Evolution of Biosynthetic Potential inMolecules (Basel, Switzerland) · 2021Article
- Targeted Genome Mining-From Compound Discovery to Biosynthetic Pathway Elucidation.Microorganisms · 2020Article
- Engineering of Streptomyces lividans for heterologous expression of secondary metabolite gene clusters.Microbial cell factories · 2020Article
- Mini review: Genome mining approaches for the identification of secondary metabolite biosynthetic gene clusters inComputational and structural biotechnology journal · 2020Review
- Genetic platforms for heterologous expression of microbial natural products.Natural product reports · 2019Review
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The genome of streptomycetes has the ability to produce many novel and potentially useful bioactive compounds, but most of which are not produced under standard laboratory cultivation conditions and are referred to as silent/cryptic secondary metabolites. Streptomyces lavendulae FRI-5 produces several types of bioactive compounds. However, this strain may also have the potential to biosynthesize more useful secondary metabolites. Here, we activated a silent biosynthetic gene cluster of an uncharacterized compound from S. lavendulae FRI-5 using heterologous expression. The engineered strain carrying the silent gene cluster produced compound 5, which was undetectable in the culture broth of S. lavendulae FRI-5. Using various spectroscopic analyses, we elucidated the chemical structure of compound 5 (named lavendiol) as a new diol-containing polyketide. The proposed assembly line of lavendiol shows a unique biosynthetic mechanism for polyketide compounds. The results of this study suggest the possibility of discovering more silent useful compounds from streptomycetes by genome mining and heterologous expression.
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