ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2018
Early vagal nerve stimulator implantation in children: personal experience and review of the literature.
Review in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 20 citations in OpenAlex.
- Efficacy of vagus nerve stimulator during transition to adulthood in patients with treatment-resistant epilepsy.Epileptic disorders : international epilepsy journal with videotape · 2026Article
- Evaluation of the outcomes of vagal nerve stimulation in children with drug-refractory epilepsy in South Africa.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Risk factors for Drug-resistant Epilepsy (DRE) and a nomogram model to predict DRE development in post-traumatic epilepsy patients.CNS neuroscience & therapeutics · 2022Article
- Altered amplitude of low-frequency fluctuations and regional homogeneity in drug-resistant epilepsy patients with vagal nerve stimulators under different current intensity.CNS neuroscience & therapeutics · 2021Article
- Subgroup analysis of seizure and cognitive outcome after vagal nerve stimulator implantation in children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Health Technology Assessment Report on Vagus Nerve Stimulation in Drug-Resistant Epilepsy.International journal of environmental research and public health · 2020Review
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimData concerning the benefit of vagal nerve stimulation (VNS) in children under the age of 12 years is sparse. It was shown that reduction of seizure frequency and duration at an early age could lead to better psychomotor development. We therefore compare the outcome between early (≤ 5 years of age) and late (> 5 years of age) implantation of VNS in children.
methodsThis study is a prospective review of patients analyzing primarily the reduction of seizure frequency and secondarily epilepsy outcome assessed by the McHugh and Engel classification, reduction of antiepileptic drugs (AED), psychomotor development measured by the Vineland Adaptive Behavior Scale (VABS), and quality of life using the caregiver impression (CGI) scale. Mean follow-up time was 36 and 31 months in the early and late group, respectively.
resultsOut of 12 consecutive VNS implantations for therapy refractory epilepsy, 5 were early implantations and 7 late implantations. Reduction of seizure frequency, McHugh and Engel classification, quality of life, psychomotor development and reduction of AED were comparable in both groups. One patient in the late group suffered from a postoperative infection resulting in explanation of the VNS device and re-implantation on the opposite side, while mortality rate was 0%.
conclusionsVNS seems to be a safe and feasible therapy in children even under the age of 5 years. Responder rate, quality of life, and psychomotor development do not seem to be influenced by the child's age at implantation; however, larger studies analyzing the outcome of early VNS implantation are warranted.
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