Evidence map›Paper›PMID 29255795›Full record

ArticleeNeuro

The Maintenance of Synaptic Homeostasis at the

Catherine J Yeates, Danielle J Zwiefelhofer, C Andrew Frank

Abstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Precise mapping of one classic and three novelmicroPublication biology · 2023
    Article
  2. Article
  3. Article
  4. Characterization ofmicroPublication biology · 2022
    Article
  5. Article
  6. Article
  7. Review
  8. Rapid and sustained homeostatic control of presynaptic exocytosis at a central synapse.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  9. Article
  10. Article
  11. The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Catherine J YeatesDepartment of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA 52242.ORCID https://orcid.org/0000-0002-7755-0612
Danielle J ZwiefelhoferDepartment of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA 52242.
C Andrew FrankDepartment of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, IA 52242.ORCID https://orcid.org/0000-0001-9599-421X

Funding

NEUROSCIENCE TRAINING PROGRAMT32NS007421 · NINDS · UNIVERSITY OF IOWA · PI Sheila A Baker, Daniel T. Tranel · 1999 to 2026
$6.0M
Synaptic signals that drive the long-term maintenance of homeostatic neuroplasticityR01NS085164 · NINDS · UNIVERSITY OF IOWA · PI FRANK, CARL ANDREW · 2017 to 2021
$1.5M
NINDS NIH HHS R01 NS085164NINDS NIH HHS T32 NS007421
6 · The paper itself

Abstract

Homeostasis is a vital mode of biological self-regulation. The hallmarks of homeostasis for any biological system are a baseline set point of physiological activity, detection of unacceptable deviations from the set point, and effective corrective measures to counteract deviations. Homeostatic synaptic plasticity (HSP) is a form of neuroplasticity in which neurons and circuits resist environmental perturbations and stabilize levels of activity. One assumption is that if a perturbation triggers homeostatic corrective changes in neuronal properties, those corrective measures should be reversed upon removal of the perturbation. We test the reversibility and limits of HSP at the well-studied

Indexed as

TemperatureAnimalsAnimals, Genetically ModifiedDrosophila melanogasterExcitatory Postsynaptic PotentialsFemaleHomeostasisLarvaMaleNeuromuscular JunctionNeuronal PlasticityReceptors, GlutamateReceptors, GlutamateDrosophilahomeostaticneuromuscularplasticityreversibilitysynapse

Identifiers

PMID29255795
PMCPMC5732017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.