Evidence map›Paper›PMID 29255671›Full record

ArticleNeuroImage. Clinical2018

Molecular and functional PET-fMRI measures of placebo analgesia in episodic migraine: Preliminary findings.

Clas Linnman, Ciprian Catana, Mike P Petkov, Daniel Burje Chonde, Lino Becerra, Jacob Hooker, David Borsook

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Advances in simultaneous PET/MR for imaging neuroreceptor function.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Review
  5. Article
  6. A Survey of Molecular Imaging of Opioid Receptors.Molecules (Basel, Switzerland) · 2019
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Clas LinnmanDepartment of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Harvard Medical School, USA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, USA. Electronic address: clas.linnman@childrens.harvard.edu.
Ciprian CatanaAthinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Mike P PetkovDepartment of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Harvard Medical School, USA; Center for Pain and the Brain, Boston Children's Hospital and Massachusetts General Hospital (MGH), Harvard Medical School, Boston, MA, USA.
Daniel Burje ChondeAthinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Lino BecerraDepartment of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Harvard Medical School, USA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, USA; Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.; Center for Pain and the Brain, Boston Children's Hospital and Massachusetts General Hospital (MGH), Harvard Medical School, Boston, MA, USA.
Jacob HookerAthinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
David BorsookDepartment of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Harvard Medical School, USA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, USA; Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.; Center for Pain and the Brain, Boston Children's Hospital and Massachusetts General Hospital (MGH), Harvard Medical School, Boston, MA, USA.
Boston Children's Hospital · USAthinoula A. Martinos Center for Biomedical Imaging · US

Funding

MR-assisted PET data optimization for neuroimaging studiesR01EB014894 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI CATANA, CIPRIAN · 2013 to 2016
$2.6M
Imaging Pain and Analgesia: Mentoring in Basic and Applied ResearchK24NS064050 · NINDS · MCLEAN HOSPITAL · PI BORSOOK, DAVID · 2008 to 2017
$1.7M
Molecular and Functional PET-fMRI Measures of Placebo Analgesia in MigraineR21AT007530 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI BORSOOK, DAVID · 2012 to 2013
$468k
NCCIH NIH HHS R21 AT007530NIBIB NIH HHS R01 EB014894NINDS NIH HHS K24 NS064050
6 · The paper itself

Abstract

Pain interventions with no active ingredient, placebo, are sometimes effective in treating chronic pain conditions. Prior studies on the neurobiological underpinnings of placebo analgesia indicate endogenous opioid release and changes in brain responses and functional connectivity during pain anticipation and pain experience in healthy subjects. Here, we investigated placebo analgesia in healthy subjects and in interictal migraine patients (n = 9) and matched healthy controls (n = 9) using

Indexed as

AnalgesiaPlacebo EffectAdultBrainFemaleHumansInjections, IntravenousMagnetic Resonance ImagingMaleMigraine DisordersMultimodal ImagingPain MeasurementPain ThresholdPlacebosPositron-Emission TomographyReceptors, OpioidPlacebosReceptors, OpioidSodium Chloride

Identifiers

PMID29255671
PMCPMC5725156
OpenAlexW2770119145

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.