ArticleVirus evolution2017
Genetic analysis of a rabies virus host shift event reveals within-host viral dynamics in a new host.
Article in Virus evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Epidemiological Analysis of Rabies Outbreaks in the European Union and Türkiye (2013-2023).Life (Basel, Switzerland) · 2026Article
- Experimental evolution of the host range dynamics in two isolates of potato virus Y.Virus evolution · 2026Article
- Reconstructing the molecular epidemiology of rabies in Switzerland from outbreak to elimination (1967-97).Virus evolution · 2026Article
- A logistic regression model to predict the next rabies virus host-shift event.Scientific reports · 2025Article
- Genomic characterization of a dog-mediated rabies outbreak in El Pedregal, Arequipa, Peru.PLoS neglected tropical diseases · 2025Article
- Phylogenetic inferences reveal multiple intra- and interhost genetic diversity among bat rabies viruses circulating in northeastern Brazil.One health outlook · 2025Article
- Oral rabies vaccination of foxes in Türkiye, 2019-2022.One health (Amsterdam, Netherlands) · 2024Article
- Burden of human rabies disease: its potential prevention by means of RabipurJournal of preventive medicine and hygiene · 2024Review
- Genomic Characterization of a Dog-Mediated Rabies Outbreak in El Pedregal, Arequipa, Peru.bioRxiv : the preprint server for biology · 2024Article
- Investigating the emergence of a zoonotic virus: phylogenetic analysis of European bat lyssavirus 1 in the UK.Virus evolution · 2024Article
- A Case Report on a Human Bite Contact with a Rabid Honey BadgerTropical medicine and infectious disease · 2023Article
- Rabies in a postpandemic world: resilient reservoirs, redoubtable riposte, recurrent roadblocks, and resolute recidivism.Animal diseases · 2023Review
- Article
- Oral Rabies Vaccine Strain SPBN GASGAS: Genetic Stability after Serial In Vitro and In Vivo Passaging.Viruses · 2022Article
- Making genomic surveillance deliver: A lineage classification and nomenclature system to inform rabies elimination.PLoS pathogens · 2022Article
- Whole-genome sequencing and phylogenetic analysis of rabies viruses from Jordan.PLoS neglected tropical diseases · 2021Article
- Experimental Lagos bat virus infection in straw-colored fruit bats: A suitable model for bat rabies in a natural reservoir species.PLoS neglected tropical diseases · 2020Article
- Quantifying and mapping the burden of human and animal rabies in Iraq.PLoS neglected tropical diseases · 2020Article
- Article
- Origins of the arctic fox variant rabies viruses responsible for recent cases of the disease in southern Ontario.PLoS neglected tropical diseases · 2019Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Host shift events play an important role in epizootics as adaptation to new hosts can profoundly affect the spread of the disease and the measures needed to control it. During the late 1990s, an epizootic in Turkey resulted in a sustained maintenance of rabies virus (RABV) within the fox population. We used Bayesian inferences to investigate whole genome sequences from fox and dog brain tissues from Turkey to demonstrate that the epizootic occurred in 1997 (±1 year). Furthermore, these data indicated that the epizootic was most likely due to a host shift from locally infected domestic dogs, rather than an incursion of a novel fox or dog RABV. No evidence was observed for genetic adaptation to foxes at consensus sequence level and dN/dS analysis suggested purifying selection. Therefore, the deep sequence data were analysed to investigate the sub-viral population during a host shift event. Viral heterogeneity was measured in all RABV samples; viruses from the early period after the host shift exhibited greater sequence variation in comparison to those from the later stage, and to those not involved in the host shift event, possibly indicating a role in establishing transmission within a new host. The transient increase in variation observed in the new host species may represent virus replication within a new environment, perhaps due to increased replication within the CNS, resulting in a larger population of viruses, or due to the lack of host constraints present in the new host reservoir.
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