Evidence map›Paper›PMID 29255606›Full record

ArticleJournal of materials chemistry. B2017

Enhanced cell uptake of fluorescent drug-loaded nanoparticles via an implantable photothermal fibrous patch for more effective cancer cell killing.

Yangyang Li, Yike Fu, Zhaohui Ren, Xiang Li, Chuanbin Mao, Gaorong Han

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of materials chemistry. B, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Application of nano-radiosensitizers in combination cancer therapy.Bioengineering & translational medicine · 2023
    Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yangyang LiState Key Laboratory of Silicon Materials, School of Materials Science and engineering, Zhejiang University, Hangzhou, Zhejiang, P. R. China 310027.
Yike FuState Key Laboratory of Silicon Materials, School of Materials Science and engineering, Zhejiang University, Hangzhou, Zhejiang, P. R. China 310027.
Zhaohui RenState Key Laboratory of Silicon Materials, School of Materials Science and engineering, Zhejiang University, Hangzhou, Zhejiang, P. R. China 310027.
Xiang LiState Key Laboratory of Silicon Materials, School of Materials Science and engineering, Zhejiang University, Hangzhou, Zhejiang, P. R. China 310027.
Chuanbin MaoState Key Laboratory of Silicon Materials, School of Materials Science and engineering, Zhejiang University, Hangzhou, Zhejiang, P. R. China 310027.
Gaorong HanState Key Laboratory of Silicon Materials, School of Materials Science and engineering, Zhejiang University, Hangzhou, Zhejiang, P. R. China 310027.

Funding

Hiring Non-toxic Virus Nanoparticles to Count Cancer Biomarker MoleculesR21CA195607 · NCI · UNIVERSITY OF OKLAHOMA · PI MAO, CHUANBIN · 2015 to 2016
$359k
NCI NIH HHS R21 CA195607
6 · The paper itself

Abstract

Great efforts have been devoted to effective delivery of therapeutics into cells for cancer therapy. The exploration of nanoparticle based drug delivery systems (DDSs) faces daunting challenges in low efficacy of intracellular delivery. Herein, a localized drug delivery device consisting of photoluminescent mesoporous silica nanoparticles (PLMSNs) and photothermal fibrous matrix was investigated. Specifically, PLMSNs modified with a pH-sensitive polydopamine (PDA) 'gatekeeper' served as a doxorubicin (DOX) carrier and could release DOX once the PLMSNs were up-taken by the cancer cells. The PLMSNs were electrostatically assembled on the surface of electrospun biodegradable poly(ε-caprolactone)/gelatin fibrous mesh incorporated with photothermal carbon nanoparticles (CNPs), leading to an implantable patch used as localized delivery platform. Comparing to free particulate DDSs, this implantable composite patch device was found to significantly enable superior cell up-taking effect and consequently enhance

Identifiers

PMID29255606
PMCPMC5730969

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.