Evidence map›Paper›PMID 29255581›Full record

ArticleMiddle East journal of digestive diseases2017

The Association between Modulating Inflammatory Cytokines and Constipation of Geriatrics in Iran.

Marjan Mokhtare, Rahele Alimoradzadeh, Shahram Agah, Hossein Mirmiranpour, Niloofar Khodabandehloo

Open access · diamondAbstract read
In one paragraph

Article in Middle East journal of digestive diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  7. Huangqi decoction ameliorated intestinal barrier dysfunctionWorld journal of gastrointestinal surgery · 2025
    Article
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  11. Epidermal functions are associated with constipation in the elderly.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Article
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  19. Frontiers in cellular and infection microbiology · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Marjan MokhtareAssistant professor of Gastroenterology ,Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran.
Rahele AlimoradzadehRezident, Internal Medicine Department, Iran University of Medical Sciences, Tehran, Iran.
Shahram AgahProfessor of Gastroenterology, Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran.
Hossein MirmiranpourAssistant Professor , Department of Biochemistry, Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran.
Niloofar KhodabandehlooAssistant Professor, Internist , Internal Medicine Department, Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran.
Iran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND The effect of changes in intestinal microbiota on constipation is contraversial. Constipation is more prevalent in elderly. Therefore, the current study was designed to assess the role of modulating inflammatory cytokines in old age patients with constipation by evaluating the serum levels of tumor necrosis factor alpha (TNF-α), interleukin 1 (IL-l), and interleukin 6 (IL-6). METHODS This case-control study was done on 100 participants, aged 65 years or higher, with and without functional constipation according to ROME III criteria (50 participants in each group). Baseline demographic, clinical characteristics, and serum levels of TNF-α, IL-1, and IL-6 were compared between the case and control groups. Independent t test and Chi-square test were used for analysis of data. RESULTS Mean levels of TNF-α, IL-1, and IL-6 were (666.80 ± 101.40 pg/mL vs. 489.20 ± 53.68 pg/mL,

Indexed as

ConstipationGeriatricsInflammatory cytokineIran

Identifiers

PMID29255581
PMCPMC5726336
OpenAlexW2766371954

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.