Evidence map›Paper›PMID 29255488›Full record

ArticleGut pathogens2017

Modulation of the main porcine enteric neuropeptides by a single low-dose of lipopolysaccharide (LPS)

Anita Mikołajczyk, Sławomir Gonkowski, Dagmara Złotkowska

Open access · goldAbstract read
In one paragraph

Article in Gut pathogens, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Impact on Human Health ofInternational journal of molecular sciences · 2024
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Neuroimmunological Implications of Subclinical Lipopolysaccharide fromInternational journal of molecular sciences · 2018
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Anita MikołajczykDepartment of Public Health, Epidemiology and Microbiology, Faculty of Health Sciences, University of Warmia and Mazury in Olsztyn, ul. Warszawska 30 Str., 10-082 Olsztyn, Poland.ORCID 0000-0002-5601-6648
Sławomir GonkowskiDepartment of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13 Str., 10-718 Olsztyn, Poland.
Dagmara ZłotkowskaDepartment of Food Immunology and Microbiology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences in Olsztyn, Tuwima 10 Str., 10-748 Olsztyn, Poland.
University of Warmia and Mazury in Olsztyn · PLInLife Institute of Animal Reproduction and Food Research, Polish Academy of Sciences · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe present research was conducted to investigate the influence of a low, single dose of LPS, which does not result in any clinical symptoms of intoxication on the expression of selected neuropeptides within the intestines of the domestic pig.

methodsThis experiment was conducted on immature female pigs of the Pitrain × Duroc breed (n = five per group). Seven days after the intravenous injection of 10 mL saline solution for control animals and 5 μg/kg b.w. (in 10 mL saline solution) LPS

resultsThe results of this research indicate that single low-dose LPS

conclusionThe exact functions of the substances studied and mechanisms of responses to LPS action depend on the sections of the intestines. The mechanisms of observed changes are not fully understood, but fluctuations in neuronal active substance levels may be connected with neurodegenerative and/or pro-inflammatory activity of LPS.

Indexed as

GALLow-dose lipopolysaccharideLPSNeuropeptidesNPYPigSalmonella EnteritidisSOMSPVIP

Identifiers

PMID29255488
PMCPMC5727943
OpenAlexW2773044629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.