Evidence map›Paper›PMID 29255469›Full record

ArticleFrontiers in immunology2017

Shared IgG Infection Signatures vs. Hemorrhage-Restricted IgA Clusters in Human Dengue: A Phenotype of Differential Class-Switch

Chung-Hao Huang, Ya-Hui Chang, Chun-Yu Lin, Wen-Hung Wang, Hui-Chung Kuan, Ya-Ju Hsieh, Yu-Wei Wang, Chung-Hsiang Yang, Jhen-Yan Chiu, Shih-Feng Tsai and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. A need to raise the bar - A systematic review of temporal trends in diagnostics for Japanese encephalitis virus infection, and perspectives for future research.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Chung-Hao HuangDivision of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Ya-Hui ChangInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Taiwan.
Chun-Yu LinDivision of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Wen-Hung WangDivision of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Hui-Chung KuanPediatrics, En Chu Kong Hospital, Sanxia, Taiwan.
Ya-Ju HsiehSinying Hospital, Tainan, Taiwan.
Yu-Wei WangSinying Hospital, Tainan, Taiwan.
Chung-Hsiang YangInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Taiwan.
Jhen-Yan ChiuHsieh Te Kuei Pediatric Clinic, HsinChu, Taiwan.
Shih-Feng TsaiInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Taiwan.
Yen-Hsu ChenDivision of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Hong-Hsing LiuInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Taiwan.
National Health Research Institutes · TWKaohsiung Medical University Chung-Ho Memorial Hospital · TWSin-Lau Christian Hospital · TWEn Chu Kong Hospital · TWKaohsiung Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phenotypic manifestations of infectious diseases are closely related to individual immune responses. Methods to extract information from patients' own immune reactions would be of great use for both diagnosis and treatment. Dengue fever is one of the diseases that clinical aggravations could occur paradoxically after humoral immunity appears. This property makes dengue fever an excellent disease model to explore. A principal component analyses (PCAs)-based framework derived from a prior vaccination study was developed. The framework was verified by successful demonstrations of known IgG signatures from a Mexico Dengue data set. Afterward the pipeline was tested upon

Indexed as

class-switchdengue feverhemorrhageIgAIgGimmune repertoireTGFβ

Identifiers

PMID29255469
PMCPMC5723002
OpenAlexW2772871745

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.