ArticleFrontiers in human neuroscience2017
Prefrontal-Amygdala Connectivity and State Anxiety during Fear Extinction Recall in Adolescents.
Article in Frontiers in human neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 57 citations in OpenAlex.
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- Puberty and NeuroDevelopment in adolescents (PANDA): a study protocol.BMC pediatrics · 2024Article
- Amygdala subdivisions exhibit aberrant whole-brain functional connectivity in relation to stress intolerance and psychotic symptoms in 22q11.2DS.Translational psychiatry · 2023Article
- Towards assessing subcortical "deep brain" biomarkers of PTSD with functional near-infrared spectroscopy.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Age-specific sex effects in extinction of conditioned fear in rodents.Frontiers in behavioral neuroscience · 2023Article
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- A systematic review of neural, cognitive, and clinical studies of anger and aggression.Current psychology (New Brunswick, N.J.) · 2022Article
- Prefrontal cortex, amygdala, and threat processing: implications for PTSD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Safety learning during development: Implications for development of psychopathology.Behavioural brain research · 2021Review
- Pavlovian Learning Processes in Pediatric Anxiety Disorders: A Critical Review.Biological psychiatry · 2021Review
- Adolescent anxiety disorders and the developing brain: comparing neuroimaging findings in adolescents and adults.General psychiatry · 2021Review
- Early Life Stress, Frontoamygdala Connectivity, and Biological Aging in Adolescence: A Longitudinal Investigation.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Age Differences in the Neural Correlates of Anxiety Disorders: An fMRI Study of Response to Learned Threat.The American journal of psychiatry · 2020Article
- Predicting Brain Functional Connectivity Using Mobile Sensing.Proceedings of the ACM on interactive, mobile, wearable and ubiquitous technologies · 2020Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While deficits in fear extinction recall have been suggested to underlie vulnerability to anxiety disorders in adolescents, the neurobiology of these deficits remain underexplored. Here we investigate the functional connectivity (FC) of the ventromedial prefrontal cortex (vmPFC) and dorsolateral PFC (dlPFC) underlying extinction recall in healthy adolescents, and assess associations between FC and state/trait anxiety. Adolescents (17) and adults (14, for comparison) completed a fear-learning paradigm involving extinction and extinction recall during a functional magnetic resonance imaging session, in which skin conductance response (SCR) was recorded. Psychophysiological interaction analyses revealed that during extinction recall there was significant negative connectivity between the vmPFC and amygdala in adults, but not adolescents. vmPFC-amygdala connectivity was positively correlated with SCR. Adolescents showed significant negative FC between the dlPFC and the left and right hippocampus, and the amygdala, which was positively correlated with state anxiety. Recall was also associated with negative connectivity between the dlPFC and thalamus, posterior cingulate cortex, fusiform gyrus, and pallidum in adolescents. These results demonstrate that fear extinction recall in healthy adolescents is associated with FC between prefrontal and limbic brain regions, and suggest that alterations in connectivity may be associated with vulnerability to anxiety in adolescence.
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