ArticleNature genetics2018
Mutations in SELENBP1, encoding a novel human methanethiol oxidase, cause extraoral halitosis.
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Article in Nature genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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73citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
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73 citing papers in PubMed, 128 citations in OpenAlex.
- Evolutionary Conservation of the Copper-Dependent Thiol Oxidase Activity of Selenium-Binding Proteins.Antioxidants (Basel, Switzerland) · 2026Article
- Fluorometric toolkit for methanethiol quantification and methanethiol oxidase activity determination in biological systems.Redox biology · 2026Article
- Correlation analysis of gut microbiota and metabolites in gastric cancer patients in plateau areas based on multi-omics technologies.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Genetics of selenoproteins and selenoprotein metabolism - An overview of current concepts and emerging aspects.Redox biology · 2026Review
- The Role of Ferroptosis in Diabetes Pathogenesis: Therapeutic Implications of Hydrogen Sulfide and Its Reactive Metabolites.Antioxidants (Basel, Switzerland) · 2026Review
- Microbial Modification Enhances Organic Sulfur Removal Capability of Chelated Iron Solution for Natural Gas.ACS omega · 2026Article
- Simultaneous and sensitive quantification of protein and low molecular weight persulfides, polysulfides and HNature communications · 2025Article
- SELENBP1 protects against kidney fibrosis in chronic kidney disease as a methanethiol oxidase.Science China. Life sciences · 2025Article
- Metabolic dysfunction-associated steatohepatitis reduces hepatic HRedox biology · 2025Article
- Black gas, bright future: HNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- High-altitude hypoxia exacerbates chemotherapy-induced myelosuppression by lowering serum G-CSF/GM-CSF and regulating apoptosis and proliferation.Discover oncology · 2025Article
- Selenium-Binding Protein 1-Deficient Dendritic Cells Protect Mice from Sepsis by Increased Treg/Th17.Antioxidants (Basel, Switzerland) · 2025Article
- Ablation of Mouse Selenium-Binding Protein 1 and 2 Elevates LDL by Disruption of Cholesterol Efflux and Lipid Metabolism.International journal of molecular sciences · 2025Article
- RBC-GEM: A genome-scale metabolic model for systems biology of the human red blood cell.PLoS computational biology · 2025Article
- Protective Role of Selenium-Binding Protein 1 (SELENBP1) in Patients with Ulcerative Colitis.Metabolites · 2024Article
- Integration of ATAC-Seq and RNA-Seq Reveals VDR-SELENBP1 Axis Promotes Adipogenesis of Porcine Intramuscular Preadipocytes.International journal of molecular sciences · 2024Article
- Multimodal AI/ML for discovering novel biomarkers and predicting disease using multi-omics profiles of patients with cardiovascular diseases.Scientific reports · 2024Article
- Selenium supplementation elevated SELENBP1 to inhibit fibroblast activation in pulmonary arterial hypertension.iScience · 2024Article
- Selenium-Binding Protein 1 (SBP1): A New Putative Player of Stress Sensing in Plants.International journal of molecular sciences · 2024Review
- Microbial assimilatory sulfate reduction-mediated HMicrobiome · 2024Article
13 more citing papers are in PubMed but not listed here.
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Authors and funding
21 authors at 8 institutions in 5 countries.
Arjan Pol *Department of Microbiology, IWWR, Faculty of Science, Radboud University, Nijmegen, The Netherlands.
G Herma Renkema *Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre (RUNMC), Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-8174-6538
Albert TangermanDepartment of Internal Medicine, RUNMC, Nijmegen, The Netherlands.
Edwin G WinkelCenter for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Udo F EngelkeTranslational Metabolic Laboratory, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre (RUNMC), Nijmegen, The Netherlands.
Arjan P M de BrouwerDepartment of Human Genetics, RUNMC, Nijmegen, The Netherlands.
Kent C LloydDepartment of Surgery, School of Medicine, and Mouse Biology Program, University of California, Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0002-5318-4144
Renee S AraizaMouse Biology Program, University of California, Davis, Davis, CA, USA.
Lambert van den HeuvelTranslational Metabolic Laboratory, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre (RUNMC), Nijmegen, The Netherlands.
Heymut OmranKlinik für Kinder und Jugendmedizin, Universitätsklinikum Münster, Münster, Germany.
Heike OlbrichKlinik für Kinder und Jugendmedizin, Universitätsklinikum Münster, Münster, Germany.
Marijn Oude ElberinkTranslational Metabolic Laboratory, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre (RUNMC), Nijmegen, The Netherlands.
Christian GilissenDepartment of Human Genetics, RUNMC, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-1693-9699
Richard J RodenburgTranslational Metabolic Laboratory, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre (RUNMC), Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0001-5227-3527
Jörn Oliver SassBioanalytics and Biochemistry, Department of Natural Sciences, Bonn-Rhein-Sieg University of Applied Sciences, Rheinbach, Germany.
K Otfried SchwabDepartment of Pediatrics and Adolescent Medicine, University Hospital Freiburg, Freiburg, Germany.
Hendrik SchäferSchool of Life Sciences, University of Warwick, Coventry, UK.
Hanka VenselaarCentre for Molecular and Biomolecular Informatics, RUNMC, Nijmegen, The Netherlands.
J Silvia SequeiraMetabolic Unit-Pediatric Department, Hospital de Dona Estefânia, CHLC, Lisbon, Portugal.
Huub J M Op den CampDepartment of Microbiology, IWWR, Faculty of Science, Radboud University, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-1990-9030
Ron A WeversTranslational Metabolic Laboratory, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre (RUNMC), Nijmegen, The Netherlands. ron.wevers@radboudumc.nl.ORCID http://orcid.org/0000-0003-2278-9746
Radboud University Nijmegen · NLKlinik und Poliklinik für Kinder- und Jugendmedizin · DEUniversity of California, Davis · USHochschule Bonn-Rhein-Sieg · DEHospital de Dona Estefânia · PTUniversity Medical Center Freiburg · DEUniversity Medical Center Groningen · NLUniversity of Warwick · GB
Funding
Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura Marcu · 2002 to 2026
$84.9MKOMP2-Phase3 Production and Phenotyping by the DTCC Consortium TCP Transfer to UC DavisUM1OD023221 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KC KENT LLOYD · 2016 to 2026
$45.7MUCD Mutant Mouse Regional Resource CenterU42OD012210 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KC KENT LLOYD · 2012 to 2026
$29.2MBiotechnology and Biological Sciences Research Council BB/H003851/1European Research Council 669371NCI NIH HHS P30 CA093373NIH HHS U42 OD012210NIH HHS UM1 OD023221
Abstract
Selenium-binding protein 1 (SELENBP1) has been associated with several cancers, although its exact role is unknown. We show that SELENBP1 is a methanethiol oxidase (MTO), related to the MTO in methylotrophic bacteria, that converts methanethiol to H
Indexed as
AnimalsBreath TestsCell LineCells, CulturedDimethyl SulfoxideHalitosisHumansMice, Inbred C57BLMice, KnockoutMutationOxidoreductasesSelenium-Binding ProteinsDimethyl SulfoxideOxidoreductasesSELENBP1 protein, humanSelenbp1 protein, mouseSelenium-Binding Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.