ArticleNature communications2017
Evolution of sequence-specific anti-silencing systems in Arabidopsis.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Convergence and conflict among telomere-specialized transposons across 60 million years of Drosophilid evolution.Genome research · 2026Article
- A functional atlas of transposon-encoded products and their integration into host networks.Nature communications · 2026Article
- Report on the seventh Japanese meeting on biological function and evolution through interactions between hosts and transposable elements.Mobile DNA · 2026Article
- Connecting Epigenetic and Genetic Diversity of LTR Retrotransposons in Sunflower (Plants (Basel, Switzerland) · 2026Article
- Article
- Plant mobile domain protein-DNA motif modules counteract Polycomb silencing to stabilize gene expression.Nature plants · 2025Article
- Deep resequencing unveils novel SNPs, InDels, and large structural variants for the clonal fingerprinting of sweet orange [Citrus sinensis (L.) Osbeck].The plant genome · 2025Article
- Evolutionary dynamics between transposable elements and their host genomes: mechanisms of suppression and escape.Current opinion in genetics & development · 2023Review
- Arms race between anti-silencing and RdDM in noncoding regions of transposable elements.EMBO reports · 2023Article
- Transposon control as a checkpoint for tissue regeneration.Development (Cambridge, England) · 2022Article
- Fast co-evolution of anti-silencing systems shapes the invasiveness of Mu-like DNA transposons in eudicots.The EMBO journal · 2022Article
- The fifth Japanese meeting on biological function and evolution through interactions between hosts and transposable elements.Mobile DNA · 2022Article
- Functional Diversification of Chromatin on Rapid Evolutionary Timescales.Annual review of genetics · 2021Review
- Review
- DNA methylation mutants inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Adaptive evolution of an essential telomere protein restricts telomeric retrotransposons.eLife · 2020Article
- EvoChromo: towards a synthesis of chromatin biology and evolution.Development (Cambridge, England) · 2019Review
- Host-transposon interactions: conflict, cooperation, and cooption.Genes & development · 2019Review
- Regulation of transposable elements by DNA modifications.Nature reviews. Genetics · 2019Review
- Evolution ofMobile DNA · 2019Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
The arms race between parasitic sequences and their hosts is a major driving force for evolution of gene control systems. Since transposable elements (TEs) are potentially deleterious, eukaryotes silence them by epigenetic mechanisms such as DNA methylation. Little is known about how TEs counteract silencing to propagate during evolution. Here, we report behavior of sequence-specific anti-silencing proteins used by Arabidopsis TEs and evolution of those proteins and their target sequences. We show that VANC, a TE-encoded anti-silencing protein, induces extensive DNA methylation loss throughout TEs. Related VANC proteins have evolved to hypomethylate TEs of completely different spectra. Targets for VANC proteins often form tandem repeats, which vary considerably between related TEs. We propose that evolution of VANC proteins and their targets allow propagation of TEs while causing minimal host damage. Our findings provide insight into the evolutionary dynamics of these apparently "selfish" sequences. They also provide potential tools to edit epigenomes in a sequence-specific manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.