ArticleScientific reports2017
A novel mode of cytokinesis without cell-substratum adhesion.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- The evolution of gene functional repertoire in Amorphea: divergent strategies across Amoebozoa, Fungi, and Metazoa.Molecular biology and evolution · 2026Article
- Actomyosin dynamics in detached cells: linking clutch model to cell migration and cytokinesis.BMC molecular and cell biology · 2025Article
- Cell-to-cell signaling in cell populations with large cell size variability.Biophysical journal · 2025Article
- Wound Repair of the Cell Membrane: Lessons fromCells · 2024Review
- Article
- Deletion of gmfA induces keratocyte-like migration in Dictyostelium.FEBS open bio · 2022Article
- Cell behaviors within a confined adhesive area fabricated using novel micropatterning methods.PloS one · 2022Article
- Article
- Regulation of the Total Cell Surface Area in DividingFrontiers in cell and developmental biology · 2020Article
- Dynamin-Like Protein B ofCells · 2019Article
- Molecular form and function of the cytokinetic ring.Journal of cell science · 2019Review
- Article
- Who Needs a Contractile Actomyosin Ring? The Plethora of Alternative Ways to Divide a Protozoan Parasite.Frontiers in cellular and infection microbiology · 2019Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytokinesis is a final step in cell division. Dictyostelium cells, a model organism for the study of cytokinesis, have multiple modes, denoted cytokinesis A, B, C, and D. All these modes have been mainly investigated using cells adhering to the substratum although they can grow in shaking suspension culture. Here, we observed how cells divide without adhering to the substratum using a new non-adhesive material. These detached cells formed the cleavage furrow but eventually failed in the final abscission. Thus, the cells cannot divide without adhesion, suggesting that they cannot divide only through the conventional cytokinesis A. However, in a long-term culture, the detached cells adhered each other to form multicellular aggregates and divided properly in these aggregates. Myosin II-null cells also formed such aggregates but could not divide in the aggregates. Several lines of experiments using mutant cells showed that the process of cytokinesis in multicellular aggregates is a novel mode utilizing a confined space in the aggregate in a myosin II-dependent manner. These results shed light on a poorly characterized mechanism of cytokinesis in multicellular spheroids or tissues. We propose to redefine and classify multiple modes of cytokinesis.
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