Trial reportBlood2018
Red cell exchange transfusions lower cerebral blood flow and oxygen extraction fraction in pediatric sickle cell anemia.
Open access · bronzeAbstract readClinical Trial
In one paragraph
Trial report in Blood, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Guidelines on the Use of Therapeutic Apheresis in Clinical Practice-Evidence-Based Approach From the Writing Committee of the American Society for Apheresis: The Tenth Special Issue.Journal of clinical apheresis · 2026Guideline
- Effect of voxelotor on cerebral perfusion and cerebral oxygen metabolism and cardiac stress in adult patients with sickle cell disease.American journal of hematology · 2025Trial
- Adding hydroxyurea to chronic transfusion therapy for sickle cell anemia reduces transfusion burden.Transfusion · 2025Trial
- The influence of voxelotor on cerebral blood flow and oxygen extraction in pediatric sickle cell disease.Blood · 2024Trial
- Economic evaluation of regular transfusions for cerebral infarct recurrence in the Silent Cerebral Infarct Transfusion Trial.Blood advances · 2021Trial
- Cerebral oxygen metabolism in adults with sickle cell disease.American journal of hematology · 2020Trial
- Trial
- Hemodynamic provocation with acetazolamide shows impaired cerebrovascular reserve in adults with sickle cell disease.Haematologica · 2019Trial
- White matter has impaired resting oxygen delivery in sickle cell patients.American journal of hematology · 2019Trial
- Focused ultrasound blood-brain barrier opening reveals a paradoxical remote metabolic response in the primate brain.Science advances · 2026Article
- Neuroimaging Biomarkers of Disease Progression and Cognitive Change in Patients With Retinal Vasculopathy With Cerebral Leukoencephalopathy.Neurology · 2026Article
- Inosine promotes erythrocyte metabolic reprogramming and restores oxygen release for rejuvenation via 2,3-BPG-PNP axis.Cell discovery · 2026Article
- Regional brain age is decreased in children with sickle cell anemia.Blood advances · 2026Article
- Review
- Elevated cerebral blood flow in distal and intermediate arterial territories in pediatric sickle cell anemia.Frontiers in neuroscience · 2026Article
- MRI signatures associated with active ischemia and disease severity in cerebral small vessel disease.Neuroimage. Reports · 2025Article
- Cerebral arterial lumens are enlarged in children and young adults with sickle cell disease compared to peers.Neuroimage. Reports · 2025Article
- Cerebral Hemodynamic Responses to Disease-Modifying and Curative Sickle Cell Disease Therapies.Neurology · 2025Article
- Hybrid diffuse optical appraisal of peripheral and cerebral changes in critically ill patients receiving red blood cell transfusion.Biophotonics discovery · 2025Article
- Cerebral Oxygen Metabolic Stress in Children and Adults With Large Vessel Vasculopathy Due to Sickle Cell Disease.Neurology · 2024Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Kristin P GuilliamsDepartment of Neurology.ORCID 0000-0002-5518-3778
Melanie E FieldsDepartment of Pediatrics, and.
Dustin K RaganDepartment of Neurology.
Cihat EldenizMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO; and.
Michael M BinkleyDepartment of Mechanical Engineering and Material Science, Washington University in St. Louis, St. Louis, MO.
Yasheng ChenDepartment of Neurology.ORCID 0000-0002-1133-452X
Liam S ComiskeyDepartment of Neurology.
Allan DoctorDepartment of Pediatrics, and.ORCID 0000-0002-6096-6400
Monica L HulbertDepartment of Pediatrics, and.ORCID 0000-0001-8933-0046
Joshua S ShimonyMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO; and.ORCID 0000-0002-6228-776X
Katie D VoMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO; and.ORCID 0000-0002-9318-4253
Robert C McKinstryMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO; and.ORCID 0000-0003-3578-4899
Hongyu AnMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO; and.ORCID 0000-0001-6459-2269
Jin-Moo LeeDepartment of Neurology.ORCID 0000-0002-3979-0906
Andria L FordDepartment of Neurology.ORCID 0000-0003-0605-8943
Mallinckrodt (United States) · USPediatrics and Genetics · USWashington University in St. Louis · US
Funding
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MWashington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4MWashington University Intellectual and Developmental Disabilities Research Center-Administrative Down Syndrome SupplementU54HD087011 · NICHD · WASHINGTON UNIVERSITY · PI CONSTANTINO, JOHN N. · 2015 to 2019
$7.1MMR-Derived Cerebral Oxygen Metabolism underlying Ischemic Vulnerability in Sickle Cell DiseaseR01HL129241 · NHLBI · WASHINGTON UNIVERSITY · PI Hongyu An, Robert A Campbell · 2015 to 2026
$6.6MSEPSIS-INDUCED RED CELL DYSFUNCTION (SIRD)R01GM113838 · NIGMS · WASHINGTON UNIVERSITY · PI DOCTOR, ALLAN, MARSHALL, GARLAND ROSS · 2015 to 2019
$4.0MCLINICAL HEMATOLOGY RESEARCH CAREER DEVELOPMENT PROGRAM AT WASHINGTON UNIVERSITYK12HL087107 · NHLBI · WASHINGTON UNIVERSITY · PI SADLER, J EVAN · 2006 to 2016
$3.8MGenetic Architecture of Acute Human Brain IschemiaR01NS085419 · NINDS · WASHINGTON UNIVERSITY · PI CRUCHAGA, CARLOS, LEE, JIN-MOO · 2014 to 2018
$2.8MRapid, robust and non-invasive cerebral oxygenation measurements using MRIR01NS082561 · NINDS · WASHINGTON UNIVERSITY · PI AN, HONGYU · 2014 to 2018
$2.8MAge-Dependence of Cerebral Oxygen Metabolism and Stroke Risk in Pediatric Sickle Cell DiseaseK23NS099472 · NINDS · WASHINGTON UNIVERSITY · PI GUILLIAMS, KRISTIN · 2017 to 2021
$951kCerebral Oxygen Metabolism and Functional Network Architecture in Pediatric Sickle Cell DiseaseK23HL136904 · NHLBI · WASHINGTON UNIVERSITY · PI FIELDS, MELANIE ERIN · 2017 to 2020
$642kNCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NHLBI NIH HHS K12 HL087107NHLBI NIH HHS K23 HL136904NHLBI NIH HHS R01 HL129241NICHD NIH HHS U54 HD087011NIGMS NIH HHS R01 GM113838NINDS NIH HHS K23 NS099472NINDS NIH HHS R01 NS082561NINDS NIH HHS R01 NS085419
Abstract
Blood transfusions are the mainstay of stroke prevention in pediatric sickle cell anemia (SCA), but the physiology conferring this benefit is unclear. Cerebral blood flow (CBF) and oxygen extraction fraction (OEF) are elevated in SCA, likely compensating for reduced arterial oxygen content (CaO
Indexed as
Anemia, Sickle CellCerebrovascular CirculationErythrocyte TransfusionMagnetic Resonance AngiographyAdolescentBlood Flow VelocityChildChild, PreschoolFemaleHumansMaleOxygenOxygen
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.