Evidence map›Paper›PMID 29255055›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Antagonistic actions of juvenile hormone and 20-hydroxyecdysone within the ring gland determine developmental transitions in

Suning Liu, Kang Li, Yue Gao, Xi Liu, Weiting Chen, Wei Ge, Qili Feng, Subba R Palli, Sheng Li

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 1 synthesis or guideline pooled it, 227 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. NFYB Integrates Hormonal Signals into Tissue Allometry by Promoting Protein Biosynthesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Review
  6. AZoological research · 2026
    Article
  7. Article
  8. Leptin Acts as a Peripheral Tropic Signal to Tune Steroidogenesis.bioRxiv : the preprint server for biology · 2026
    Article
  9. Review
  10. Article
  11. Article
  12. Single-cell transcriptomics of theProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  13. Mating regulates growth, metabolism, and digestive efficiency in the femaleProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  14. Article
  15. Article
  16. Lipids in Insect Reproduction: Where, How, and Why.Advances in experimental medicine and biology · 2026
    Review
  17. Article
  18. Article
  19. Article
  20. Article

56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Suning LiuGuangzhou Key Laboratory of Insect Development Regulation and Application Research, School of Life Sciences, South China Normal University, Guangzhou, 510631, China.
Kang LiGuangzhou Key Laboratory of Insect Development Regulation and Application Research, School of Life Sciences, South China Normal University, Guangzhou, 510631, China.
Yue GaoGuangzhou Key Laboratory of Insect Development Regulation and Application Research, School of Life Sciences, South China Normal University, Guangzhou, 510631, China.
Xi LiuKey Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200032, China.
Weiting ChenFaculty of Health Science, University of Macau, Macau, 00853, China.
Wei GeFaculty of Health Science, University of Macau, Macau, 00853, China.
Qili FengGuangzhou Key Laboratory of Insect Development Regulation and Application Research, School of Life Sciences, South China Normal University, Guangzhou, 510631, China.
Subba R PalliDepartment of Entomology, College of Agriculture, Food, and Environment, University of Kentucky, Lexington, KY 40546.
Sheng LiGuangzhou Key Laboratory of Insect Development Regulation and Application Research, School of Life Sciences, South China Normal University, Guangzhou, 510631, China; lisheng@scnu.edu.cn.ORCID 0000-0002-4217-2367
South China Normal University · CNUniversity of Macau · MOChinese Academy of Sciences · CNUniversity of Kentucky · US

Funding

Molecular Analysis of Juvenile Hormone ActionR01GM070559 · NIGMS · UNIVERSITY OF KENTUCKY · PI PALLI, SUBBA R · 2005 to 2024
$4.1M
NIGMS NIH HHS R01 GM070559
6 · The paper itself

Abstract

In both vertebrates and insects, developmental transition from the juvenile stage to adulthood is regulated by steroid hormones. In insects, the steroid hormone, 20-hydroxyecdysone (20E), elicits metamorphosis, thus promoting this transition, while the sesquiterpenoid juvenile hormone (JH) antagonizes 20E signaling to prevent precocious metamorphosis during the larval stages. However, not much is known about the mechanisms involved in cross-talk between these two hormones. In this study, we discovered that in the ring gland (RG) of

Indexed as

AnimalsCorpora AllataDrosophila melanogasterDrosophila ProteinsEcdysteroneGene Expression Regulation, DevelopmentalJuvenile HormonesKruppel-Like Transcription FactorsMetamorphosis, BiologicalSignal TransductionDrosophila ProteinsEcdysteroneJuvenile HormonesKr-h1 protein, DrosophilaKruppel-Like Transcription Factors20-hydroxyecdysoneantagonistic actionhormone biosynthesisjuvenile hormonering gland

Identifiers

PMID29255055
PMCPMC5776822
OpenAlexW2777420033

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.