ArticleProceedings of the National Academy of Sciences of the United States of America2018
Enzyme leaps fuel antichemotaxis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Emergent Nonlinearity in Active Molecular Chemotaxis.ACS nano · 2026Article
- Artificial chemotaxis in micro/nanomotors.Nature communications · 2026Review
- Enhanced Diffusion of Single, Lipid-Tethered Enzymes.Nano letters · 2026Article
- Interactions Between Active Matters and Endogenous Fields.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Collective Dynamics of Urease-Based Nanomotors in a Chemical Gradient.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Force Generation by Enhanced Diffusion in Enzyme-Loaded Vesicles.Nano letters · 2025Article
- Mechanochemical active ratchet.Scientific reports · 2023Article
- Ligand-binding assay based on microfluidic chemotaxis of porphyrin receptors.Chemical science · 2022Article
- Response to Comment on "Following Molecular Mobility during Chemical Reactions: No Evidence for Active Propulsion" and "Molecular Diffusivity of Click Reaction Components: The Diffusion Enhancement Question".Journal of the American Chemical Society · 2022Article
- Tunable metal hydroxide-organic frameworks for catalysing oxygen evolution.Nature materials · 2022Article
- Perspective: a stirring role for metabolism in cells.Molecular systems biology · 2022Review
- Displacement Statistics of Unhindered Single Molecules Show no Enhanced Diffusion in Enzymatic Reactions.Journal of the American Chemical Society · 2022Article
- Chemotactic smoothing of collective migration.eLife · 2022Article
- Sustained enzymatic activity and flow in crowded protein droplets.Nature communications · 2021Article
- Chemotactic migration of bacteria in porous media.Biophysical journal · 2021Article
- Nanoscale Catalyst Chemotaxis Can Drive the Assembly of Functional Pathways.The journal of physical chemistry. B · 2021Article
- Single-particle diffusional fingerprinting: A machine-learning framework for quantitative analysis of heterogeneous diffusion.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Chemically-powered swimming and diffusion in the microscopic world.Nature reviews. Chemistry · 2021Review
- Fundamentals and applications of enzyme powered micro/nano-motors.Bioactive materials · 2021Review
- A thermodynamic perspective on enhanced enzyme diffusion.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is mounting evidence that enzyme diffusivity is enhanced when the enzyme is catalytically active. Here, using superresolution microscopy [stimulated emission-depletion fluorescence correlation spectroscopy (STED-FCS)], we show that active enzymes migrate spontaneously in the direction of lower substrate concentration ("antichemotaxis") by a process analogous to the run-and-tumble foraging strategy of swimming microorganisms and our theory quantifies the mechanism. The two enzymes studied, urease and acetylcholinesterase, display two families of transit times through subdiffraction-sized focus spots, a diffusive mode and a ballistic mode, and the latter transit time is close to the inverse rate of catalytic turnover. This biochemical information-processing algorithm may be useful to design synthetic self-propelled swimmers and nanoparticles relevant to active materials. Executed by molecules lacking the decision-making circuitry of microorganisms, antichemotaxis by this run-and-tumble process offers the biological function to homogenize product concentration, which could be significant in situations when the reactant concentration varies from spot to spot.
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