ArticleProceedings of the National Academy of Sciences of the United States of America2018
Accurate quantification of brown adipose tissue mass by xenon-enhanced computed tomography.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 30 citations in OpenAlex.
- Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets.MedComm · 2026Review
- PCPE-1 promotes cardiac fibrosis with aging and obesity.JCI insight · 2026Article
- Imaging Brown Adipose Tissue: Current State and Future Perspective.Theranostics · 2025Review
- Article
- Automatic segmentation of the interscapular brown adipose tissue in rats based on deep learning using the dynamic magnetic resonance fat fraction images.Magma (New York, N.Y.) · 2024Article
- Are MTV and TLG Accurate for Quantifying the Intensity of Brown Adipose Tissue Activation?Biomedicines · 2024Article
- Absolute thermometry of human brown adipose tissue by magnetic resonance with laser polarizedCommunications medicine · 2023Article
- In-vivo detection of white adipose tissue browning: a multimodality imaging approach.Scientific reports · 2023Article
- Automatic segmentation of human supraclavicular adipose tissue using high-resolution T2-weighted magnetic resonance imaging.Magma (New York, N.Y.) · 2023Article
- Imaging Brown Adipose Tissue with TSPO PET Tracers in Preclinical Animal Studies.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Brief Communication: Histological Assessment of Nonhuman Primate Brown Adipose Tissue Highlights the Importance of Sympathetic Innervation.Journal of obesity · 2023Article
- In vivo imaging of brown adipose tissue vasculature reactivity during adrenergic stimulation of non-shivering thermogenesis in mice.Scientific reports · 2022Article
- Xenon-enhanced computed tomography assessment of brown adipose tissue distribution and perfusion in lean, obese, and diabetic primates.Obesity (Silver Spring, Md.) · 2022Article
- Obesity III: Obesogen assays: Limitations, strengths, and new directions.Biochemical pharmacology · 2022Review
- Mouse model of the adipose organ: the heterogeneous anatomical characteristics.Archives of pharmacal research · 2021Review
- Molecular Imaging of Brown Adipose Tissue Mass.International journal of molecular sciences · 2021Review
- Rotator cuff tear degeneration and the role of fibro-adipogenic progenitors.Annals of the New York Academy of Sciences · 2021Review
- Recommendations for Standardizing Thorax PET-CT in Non-Human Primates by Recent Experience from Macaque Studies.Animals : an open access journal from MDPI · 2021Article
- Magnetic Resonance Imaging Techniques for Brown Adipose Tissue Detection.Frontiers in endocrinology · 2020Review
- Morphology of the Vasculature and Blood Supply of the Brown Adipose Tissue Examined in an Animal Model by Micro-CT.BioMed research international · 2020Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Detection and quantification of brown adipose tissue (BAT) mass remains a major challenge, as current tomographic imaging techniques are either nonspecific or lack the necessary resolution to quantify BAT mass, especially in obese phenotypes, in which this tissue may be present but inactive. Here, we report quantification of BAT mass by xenon-enhanced computed tomography. We show that, during stimulation of BAT thermogenesis, the lipophilic gas xenon preferentially accumulates in BAT, leading to a radiodensity enhancement comparable to that seen in the lungs. This enhancement is mediated by a selective reduction in BAT vascular resistance, which greatly increases vascular perfusion of BAT. This enhancement enables precise identification and quantification of BAT mass not only in lean, but also in obese, mouse phenotypes, in which this tissue is invisible to conventional tomographic imaging techniques. The method is developed and validated in rodents and then applied in macaques to assess its feasibility in larger species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.