ArticleProceedings of the National Academy of Sciences of the United States of America2018
Closing the loop on impulsivity via nucleus accumbens delta-band activity in mice and man.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 104 citations in OpenAlex.
- Closed-loop transcranial alternating current stimulation (tACS) reduces cue reactivity and improves inhibitory control in methamphetamine use disorder with frequency and timing specificity.Molecular psychiatry · 2026Article
- Brain-wide activity mapping reveals the somatosensory cortex as a sex-specific regulator of hedonic feeding.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Cross-species brain-wide mapping reveals convergent mesocorticolimbic engagement by nucleus accumbens deep brain stimulation.Molecular psychiatry · 2026Article
- Semaglutide alters behaviour and nucleus accumbens oscillatory activity in healthy mice.Molecular brain · 2026Article
- Divergent Roles of Nucleus Accumbens D1- and D2-MSNs in Regulating Hedonic Feeding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Electrographic cue-reactivity co-localizes with accumbens deep brain stimulation in a case of opioid use disorder.Nature communications · 2026Article
- Electrophysiology and Functional Magnetic Resonance Imaging of Cue Craving: Potential Biomarkers for Therapeutic Neuromodulation in Addiction.Biological psychiatry global open science · 2026Review
- Change in brain molecular landscapes following electrical stimulation of the nucleus accumbens.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Brain activity associated with breakthrough food preoccupation in an individual on tirzepatide.Nature medicine · 2025Article
- Novel potential pharmacological approaches in treating eating disorders comorbid with substance use disorders.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025Review
- Multimodal objective assessment of impulsivity in healthy and mood disorder participants.NPP - digital psychiatry and neuroscience · 2025Article
- Intracranial closed-loop neuromodulation as an intervention for neuropsychiatric disorders: an overview.Frontiers in psychiatry · 2025Review
- Emerging neuromodulation treatments for opioid and stimulant use disorders.Frontiers in human neuroscience · 2025Review
- Harnessing the sensing and stimulation function of deep brain-machine interfaces: a new dawn for overcoming substance use disorders.Translational psychiatry · 2024Review
- Brain-computer interfaces for neuropsychiatric disorders.Nature reviews bioengineering · 2024Article
- More widespread and rigid neuronal representation of reward expectation underlies impulsive choices.bioRxiv : the preprint server for biology · 2024Article
- Transcranial Direct Current Stimulation Decreases P3 Amplitude and Inherent Delta Activity during a Waiting Impulsivity Paradigm: Crossover Study.Brain sciences · 2024Article
- Continuous deep brain stimulation of the nucleus accumbens reduces food intake but does not affect body weight in mice fed a high-fat diet.Scientific reports · 2023Article
- Signatures of Electrical Stimulation Driven Network Interactions in the Human Limbic System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Neural oscillations in the ventral striatum reveal differences between the encoding of palatable food and ethanol consumption.Alcohol, clinical & experimental research · 2023Article
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
Abstract
Reward hypersensitization is a common feature of neuropsychiatric disorders, manifesting as impulsivity for anticipated incentives. Temporally specific changes in activity within the nucleus accumbens (NAc), which occur during anticipatory periods preceding consummatory behavior, represent a critical opportunity for intervention. However, no available therapy is capable of automatically sensing and therapeutically responding to this vulnerable moment in time when anticipation-related neural signals may be present. To identify translatable biomarkers for an off-the-shelf responsive neurostimulation system, we record local field potentials from the NAc of mice and a human anticipating conventional rewards. We find increased power in 1- to 4-Hz oscillations predominate during reward anticipation, which can effectively trigger neurostimulation that reduces consummatory behavior in mice sensitized to highly palatable food. Similar oscillations are present in human NAc during reward anticipation, highlighting the translational potential of our findings in the development of a treatment for a major unmet need.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.