Evidence map›Paper›PMID 29255038›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Epigenetic control of pheromone MAPK signaling determines sexual fecundity in

Christine M Scaduto, Shail Kabrawala, Gregory J Thomson, William Scheving, Andy Ly, Matthew Z Anderson, Malcolm Whiteway, Richard J Bennett

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Genetic and environmental control of parasexual reproduction in the pathogenicMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  3. White-opaque switching inMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  4. Article
  5. Article
  6. Epistatic genetic interactions govern morphogenesis during sexual reproduction and infection in a global human fungal pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  7. Article
  8. Article
  9. Parasexuality ofFrontiers in cellular and infection microbiology · 2021
    Review
  10. Microorganisms · 2020
    Review
  11. Unraveling HowJournal of fungi (Basel, Switzerland) · 2020
    Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Christine M ScadutoDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912.
Shail KabrawalaDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912.
Gregory J ThomsonDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912.
William SchevingDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912.
Andy LyDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912.
Matthew Z AndersonDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912.ORCID 0000-0003-1683-2170
Malcolm WhitewayDepartment of Biology, Concordia University, Montreal, QC, Canada H4B 1R6.
Richard J BennettDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912; Richard_Bennett@brown.edu.
Brown University · USConcordia University · CA

Funding

Transcriptional Regulation of C. albicans Cell Fate and Host InteractionsR01AI081704 · NIAID · BROWN UNIVERSITY · PI Richard John Bennett · 2010 to 2026
$6.4M
TRAINING IN MOLECULAR &CELL BIOLOGY &BIOCHEMISTRYT32GM007601 · NIGMS · BROWN UNIVERSITY · PI MOWRY, KIMBERLY L. · 1985 to 2019
$6.4M
Development of Quantitative Genetics Approaches in Candida albicansR21AI122011 · NIAID · BROWN UNIVERSITY · PI BENNETT, RICHARD JOHN · 2016 to 2017
$450k
Epigenetic Regulation of Sexual Mating and Biofilm formation in Candida albicansF31DE024036 · NIDCR · BROWN UNIVERSITY · PI SCADUTO, CHRISTINE MARIA · 2014 to 2016
$132k
NIAID NIH HHS R01 AI081704NIAID NIH HHS R21 AI122011NIDCR NIH HHS F31 DE024036NIGMS NIH HHS T32 GM007601
6 · The paper itself

Abstract

Several pathogenic

Indexed as

Candida albicansEpigenesis, GeneticGene Expression Regulation, FungalMAP Kinase Signaling SystemPheromonesPheromonesmatingphenotypic switchingsexual reproductionsignaling bottleneckstranscriptional regulation

Identifiers

PMID29255038
PMCPMC5748179
OpenAlexW2776686103

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.