ArticleProceedings of the National Academy of Sciences of the United States of America2018
Behavioral state modulates the ON visual motion pathway of
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
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- Connectome-driven neural inventory of a complete visual system.bioRxiv : the preprint server for biology · 2024Article
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- Social state gates vision using three circuit mechanisms inbioRxiv : the preprint server for biology · 2024Article
- Facemap: a framework for modeling neural activity based on orofacial tracking.Nature neuroscience · 2024Article
- Neural mechanisms to incorporate visual counterevidence in self-movement estimation.Current biology : CB · 2023Article
- A comprehensive neuroanatomical survey of thebioRxiv : the preprint server for biology · 2023Article
- Long-timescale anti-directional rotation ineLife · 2023Article
- The spatial and temporal structure of neural activity across the fly brain.Nature communications · 2023Article
- Threat gates visual aversion via theta activity in Tachykinergic neurons.Nature communications · 2023Article
- Neural mechanisms to incorporate visual counterevidence in self motion estimation.bioRxiv : the preprint server for biology · 2023Article
- Long timescale anti-directional rotation in Drosophila optomotor behavior.bioRxiv : the preprint server for biology · 2023Article
- Bioinspired figure-ground discrimination via visual motion smoothing.PLoS computational biology · 2023Article
- Mushroom body output neurons MBON-a1/a2 define an odor intensity channel that regulates behavioral odor discrimination learning in larvalFrontiers in physiology · 2023Article
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7 authors.
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Abstract
The behavioral state of an animal can dynamically modulate visual processing. In flies, the behavioral state is known to alter the temporal tuning of neurons that carry visual motion information into the central brain. However, where this modulation occurs and how it tunes the properties of this neural circuit are not well understood. Here, we show that the behavioral state alters the baseline activity levels and the temporal tuning of the first directionally selective neuron in the ON motion pathway (T4) as well as its primary input neurons (Mi1, Tm3, Mi4, Mi9). These effects are especially prominent in the inhibitory neuron Mi4, and we show that central octopaminergic neurons provide input to Mi4 and increase its excitability. We further show that octopamine neurons are required for sustained behavioral responses to fast-moving, but not slow-moving, visual stimuli in walking flies. These results indicate that behavioral-state modulation acts directly on the inputs to the directionally selective neurons and supports efficient neural coding of motion stimuli.
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