ArticleProceedings of the National Academy of Sciences of the United States of America2018
In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of
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In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 149 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
149citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
149 citing papers in PubMed, 2 syntheses or guidelines pooled it, 205 citations in OpenAlex.
- Tryptophan and Its Derived Metabolites as Biomarkers for Tuberculosis Disease: A Systematic ReviewIranian biomedical journal · 2024Pooled it
- The immunoregulatory landscape of human tuberculosis granulomas.Nature immunology · 2022Pooled it
- Tryptophan catabolism reflects disease activity in human tuberculosis.JCI insight · 2020Trial
- Tuberculosis in Pregnancy: Challenges of Immune Protection.The Journal of infectious diseases · 2026Review
- Therapeutic remodeling of the tuberculosis granuloma with 1-methyl-D-tryptophan enhances CD8Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Kynurenine Pathway in Tuberculosis: Focus on Immunometabolic Regulation, Compartment-Specific Biology, and Therapeutic Potential.Life (Basel, Switzerland) · 2026Review
- Pathogenesis of Tuberculosis: Interplay Between Host Antituberculosis Immunity and Immune Evasion Strategies ofMedComm · 2026Review
- The host immune response to Mycobacterium tuberculosis determining protection or disease progression.Nature immunology · 2026Review
- Circulating metabolites associated with protection against Mycobacterium tuberculosis infection and inhibition of mycobacterial growth.Communications biology · 2026Article
- HCellular & molecular biology letters · 2026Article
- Expression of CD103 facilitates localization and activation of CD4Mucosal immunology · 2026Article
- The immunometabolic topography of cellular organization and bacterial control in tuberculosis granulomas.Nature immunology · 2026Article
- Integrated metabolomic and transcriptomic analysis reveals novel plasma biomarkers and metabolic pathway dysregulation in latent tuberculosis infection.Microbiology spectrum · 2026Article
- Post-TB lung disease: pathogenesis, host-directed therapies, and the C3HeB/FeJ model for pre-clinical advances.Infection and immunity · 2026Review
- Type I interferons in tuberculosis pathogenesis and prevention.Trends in microbiology · 2026Review
- Targeting Tryptophan Metabolism for Tuberculosis Biomarkers and Host-Directed Therapy.The Journal of infectious diseases · 2026Review
- Insights into the host response to 'dormant' Mycobacterium tuberculosis utilizing 'Vitamin C-induced dormant Mtb' THP-1 cell infection model.BMC genomics · 2026Article
- Multicohort assessment of plasma metabolic signatures of tuberculosis disease in children: a retrospective cross-sectional study.Scientific reports · 2026Article
- Feeding the invaders: how metabolic imbalance shapes infection and biofilm development.FEMS microbiology reviews · 2026Review
- T cell-macrophage interactions in tuberculosis: What we've got here is failure to communicate.Journal of internal medicine · 2026Review
89 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 4 institutions in 1 country.
Uma S GautamTulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433.
Taylor W ForemanTulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433.
Allison N BucsanTulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433.
Ashley V VeatchTulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433.
Xavier AlvarezTulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433.
Toidi AdekambiEmory Vaccine Center, Emory University, Atlanta, GA 30322.
Nadia A GoldenTulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433.
Kaylee M GentryTulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433.
Lara A Doyle-MeyersTulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433.
Kasi E Russell-LodrigueTulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433.ORCID 0000-0003-3719-0779
Peter J DidierTulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433.
James L BlanchardTulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433.
K Gus KousoulasDepartment of Pathobiological Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA 70803.
Andrew A LacknerTulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433.
Daniel KalmanDepartment of Pathobiological Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA 70803.
Jyothi RengarajanEmory Vaccine Center, Emory University, Atlanta, GA 30322.
Shabaana A KhaderDepartment of Molecular Microbiology, Washington University in St. Louis, St. Louis, MO 63130.
Deepak KaushalTulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433; dkaushal@tulane.edu smehra@lsu.edu.
Smriti MehraTulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433; dkaushal@tulane.edu smehra@lsu.edu.ORCID 0000-0002-7942-0010
Tulane University · USEmory University · USLouisiana State University · USWashington University in St. Louis · US
Funding
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0MTulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4MVirology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Carlos del Rio · 2002 to 2026
$74.0MBAA-NIH-NIAID-NCRR-DMID-03-036UC6AI058609 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI LACKNER, ANDREW A · 2003 to 2006
$21.1MROLE OF INDUCIBLE BRONCHUS ASSOCIATED LYMPHOID TISSUE IN LATENT TUBERCULOSISR01AI111914 · NIAID · WASHINGTON UNIVERSITY · PI KAUSHAL, DEEPAK, KHADER, SHABAANA A. · 2015 to 2025
$11.1MMyeloid and lymphoid immunity-specific mechanisms of IDO mediated immunosuppression and its reversal, during TBR01AI134245 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI Smriti Mehra · 2018 to 2026
$6.2MProtein CoreP30GM110760 · NIGMS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI KOUSOULAS, KONSTANTIN G · 2014 to 2018
$5.6MImmune Correlates of Protection from TBR01AI134240 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI KAUSHAL, DEEPAK · 2017 to 2022
$4.8MPerturbation of antigen-specific T cell responses in latent TB/SIV co-infectionR01AI111943 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI KAUSHAL, DEEPAK, RENGARAJAN, JYOTHI · 2015 to 2019
$3.9MImpact of concurrent HIV and latent TB therapies on Mtb-specific immune function-Diversity SupplementR01AI123047 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI KAUSHAL, DEEPAK, RENGARAJAN, JYOTHI · 2017 to 2020
$3.9MGenetic Requirements for the survival of Tubercle Bacilli in Nonhuman PrimatesR01AI089323 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI KAUSHAL, DEEPAK · 2010 to 2014
$3.2MTranscriptomics of Tuberculosis Latency and Reactivation in PrimatesR01HL106790 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI KAUSHAL, DEEPAK · 2010 to 2013
$3.1MNHLBI NIH HHS R01 HL106790NIAID NIH HHS P30 AI050409NIAID NIH HHS R01 AI089323NIAID NIH HHS R01 AI111914NIAID NIH HHS R01 AI111943NIAID NIH HHS R01 AI123047NIAID NIH HHS R01 AI123780NIAID NIH HHS R01 AI134240NIAID NIH HHS R01 AI134245NIAID NIH HHS R21 AI127160NIAID NIH HHS R21 AI127172NIAID NIH HHS R21 AI127222NIAID NIH HHS R21 AI128130NIAID NIH HHS UC6 AI058609NIGMS NIH HHS P30 GM110760NIH HHS P51 OD011104NIH HHS P51 OD011132NIH HHS S10 OD019964
Abstract
PubMed holds no abstract for this paper.
Indexed as
AnimalsCD4-Positive T-LymphocytesCell ProliferationGranulomaIndoleamine-Pyrrole 2,3,-DioxygenaseLungMacaca mulattaMacrophagesMycobacterium tuberculosisTryptophanTuberculomaTuberculosis, PulmonaryIndoleamine-Pyrrole 2,3,-DioxygenaseTryptophangranulomaIDOmacaqueT celltuberculosis
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.