ArticleProceedings of the National Academy of Sciences of the United States of America2018
Lesion network localization of criminal behavior.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05444907 (Understanding Deep Brain Stimulation-induced Mania), which is not on this map. Cited by 98 papers, 13 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Understanding Deep Brain Stimulation-induced Mania: Finding Potential Predictors to Optimize Treatment
Who cites it
98 citing papers in PubMed, 13 syntheses or guidelines pooled it, 207 citations in OpenAlex.
- Network localization of regional intrinsic neural activity alterations in migraine and their neurochemical correlates.Frontiers in neurology · 2026Pooled it
- Common neural dysfunction in psychiatric disorders: Insights from a meta-analysis of resting-state fMRI studies.Translational psychiatry · 2025Pooled it
- Traumatic Brain Injury and Related Antisocial Behavioral Outcomes: A Systematic Review.Medicina (Kaunas, Lithuania) · 2023Pooled it
- A neural network for tics: insights from causal brain lesions and deep brain stimulation.Brain : a journal of neurology · 2022Pooled it
- Activation network mapping for integration of heterogeneous fMRI findings.Nature human behaviour · 2022Pooled it
- Neural substrates of motivational dysfunction across neuropsychiatric conditions: Evidence from meta-analysis and lesion network mapping.Clinical psychology review · 2022Pooled it
- Idiopathic and acquired pedophilia as two distinct disorders: an insight from neuroimaging.Brain imaging and behavior · 2021Pooled it
- Rapid eye movement sleep patterns of brain activation and deactivation occur within unique functional networks.Human brain mapping · 2020Pooled it
- Right-sided brain lesions predominate among patients with lesional mania: evidence from a systematic review and pooled lesion analysis.Translational psychiatry · 2020Pooled it
- Mapping holmes tremor circuit using the human brain connectome.Annals of neurology · 2019Pooled it
- Love is analogous to money in human brain: Coordinate-based and functional connectivity meta-analyses of social and monetary reward anticipation.Neuroscience and biobehavioral reviews · 2019Pooled it
- Network localization of heterogeneous neuroimaging findings.Brain : a journal of neurology · 2019Pooled it
- Gender and Hemispheric Asymmetries in Acquired Sociopathy.Frontiers in psychology · 2019Pooled it
- Linking Personalized Brain Atrophy to Schizophrenia Network and Treatment Response.Schizophrenia bulletin · 2023Trial
- A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder.Nature communications · 2020Trial
- Neurobiological Determinism versus Human Freedom: Competing Explanatory Models and the Hope for Moral Enhancement.The Journal of medicine and philosophy · 2026Article
- When crime signals cortex: frontotemporal dementia presenting as late-onset criminality and the case for neuroimaging in geriatric offenders.Annals of medicine and surgery (2012) · 2026Article
- Remote network for cognitive symptoms derived from tau accumulation in progressive supranuclear palsy.Science advances · 2026Article
- Brain Structural and Functional Alteration Network Localization of Visual Hallucinations.Schizophrenia bulletin · 2026Article
- Multimodal network localization of brain abnormalities and neuromodulation target identification in obsessive-compulsive disorder.Scientific reports · 2026Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Following brain lesions, previously normal patients sometimes exhibit criminal behavior. Although rare, these cases can lend unique insight into the neurobiological substrate of criminality. Here we present a systematic mapping of lesions with known temporal association to criminal behavior, identifying 17 lesion cases. The lesion sites were spatially heterogeneous, including the medial prefrontal cortex, orbitofrontal cortex, and different locations within the bilateral temporal lobes. No single brain region was damaged in all cases. Because lesion-induced symptoms can come from sites connected to the lesion location and not just the lesion location itself, we also identified brain regions functionally connected to each lesion location. This technique, termed lesion network mapping, has recently identified regions involved in symptom generation across a variety of lesion-induced disorders. All lesions were functionally connected to the same network of brain regions. This criminality-associated connectivity pattern was unique compared with lesions causing four other neuropsychiatric syndromes. This network includes regions involved in morality, value-based decision making, and theory of mind, but not regions involved in cognitive control or empathy. Finally, we replicated our results in a separate cohort of 23 cases in which a temporal relationship between brain lesions and criminal behavior was implied but not definitive. Our results suggest that lesions in criminals occur in different brain locations but localize to a unique resting state network, providing insight into the neurobiology of criminal behavior.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.