Evidence map›Paper›PMID 29255013›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Evolutionary transition from blood feeding to obligate nonbiting in a mosquito.

William E Bradshaw, Joshua Burkhart, John K Colbourne, Rudyard Borowczak, Jacqueline Lopez, David L Denlinger, Julie A Reynolds, Michael E Pfrender, Christina M Holzapfel

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
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  14. Article
  15. Olfactory systems across mosquito species.Cell and tissue research · 2021
    Review
  16. Article
  17. eLife · 2020
    Article
  18. Review
  19. Article
  20. Molecular pathways to nonbiting mosquitoes.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

William E BradshawLaboratory of Evolutionary Genetics, Institute of Ecology and Evolution, University of Oregon, Eugene, OR 97403; mosquito@uoregon.edu denlinger.1@osu.edu.
Joshua BurkhartLaboratory of Evolutionary Genetics, Institute of Ecology and Evolution, University of Oregon, Eugene, OR 97403.
John K ColbourneSchool of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
Rudyard BorowczakLaboratory of Evolutionary Genetics, Institute of Ecology and Evolution, University of Oregon, Eugene, OR 97403.
Jacqueline LopezDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556.
David L DenlingerDepartment of Entomology, The Ohio State University, Columbus, OH 43210; mosquito@uoregon.edu denlinger.1@osu.edu.
Julie A ReynoldsDepartment of Entomology, The Ohio State University, Columbus, OH 43210.
Michael E PfrenderDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556.
Christina M HolzapfelLaboratory of Evolutionary Genetics, Institute of Ecology and Evolution, University of Oregon, Eugene, OR 97403; mosquito@uoregon.edu denlinger.1@osu.edu.

Funding

TRAINING PROGRAM IN HEALTH INFORMATICST15LM007088 · NLM · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAM R HERSH, Vishnu Mohan · 1992 to 2026
$23.4M
6 · The paper itself

Abstract

The spread of blood-borne pathogens by mosquitoes relies on their taking a blood meal; if there is no bite, there is no disease transmission. Although many species of mosquitoes never take a blood meal, identifying genes that distinguish blood feeding from obligate nonbiting is hampered by the fact that these different lifestyles occur in separate, genetically incompatible species. There is, however, one unique extant species with populations that share a common genetic background but blood feed in one region and are obligate nonbiters in the rest of their range:

Indexed as

Evolution, MolecularFeeding BehaviorAnimalsBloodBlood-Borne PathogensCulicidaeFemaleGene ExpressionGenes, InsectGenetics, PopulationHumansInsect Bites and StingsInsect ProteinsMetabolic Networks and PathwaysModels, BiologicalMosquito VectorsInsect Proteinsdirectional selectiongenetic backgroundgenomicsKEGG metabolic pathwaysmalaria

Identifiers

PMID29255013
PMCPMC5798368

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.