Evidence map›Paper›PMID 29255003›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Loss of Intercalated Cells (ITCs) in the Mouse Amygdala of

Jeffrey Kuerbitz, Melinda Arnett, Sarah Ehrman, Michael T Williams, Charles V Vorhees, Simon E Fisher, Alistair N Garratt, Louis J Muglia, Ronald R Waclaw, Kenneth Campbell

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 56 citations in OpenAlex.

  1. Review
  2. Fine mapping of PTSD GWAS reveals a role for amygdalabioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 6 countries.

Jeffrey KuerbitzDivisions of Developmental Biology.ORCID 0000-0003-4821-6305
Melinda ArnettCenter for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229.
Sarah EhrmanDivisions of Developmental Biology.
Michael T WilliamsNeurology.ORCID 0000-0001-9841-9683
Charles V VorheesNeurology.ORCID 0000-0003-3558-8812
Simon E FisherLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, 6500 AH Nijmegen, The Netherlands.ORCID 0000-0002-3132-1996
Alistair N GarrattInstitute of Cell Biology and Neurobiology, Center for Anatomy, Charité University Hospital Berlin, 10117 Berlin, Germany.
Louis J MugliaCenter for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229.ORCID 0000-0002-0301-8770
Ronald R WaclawDivisions of Developmental Biology.
Kenneth CampbellDivisions of Developmental Biology, kenneth.campbell@cchmc.org.ORCID 0000-0001-5666-8008
Cincinnati Children's Hospital Medical Center · USNeurology, Inc · USSociety for Developmental and Behavioral Pediatrics · USCharité - Universitätsmedizin Berlin · DEForthnet (Greece) · GRLaboratoire d’immunologie intégrative du cancer · FRRadboud University Nijmegen · NL

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
Medical Scientist Training ProgramT32GM063483 · NIGMS · UNIVERSITY OF CINCINNATI · PI KHURANA HERSHEY, GURJIT K. · 2002 to 2022
$6.7M
Roles of Gsx factors in telencephalic neurogenesisR01NS044080 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI CAMPBELL, KENNETH J, GEBELEIN, BRIAN · 2002 to 2018
$5.9M
Short Term Medical Student Training GrantT35DK060444 · NIDDK · UNIVERSITY OF CINCINNATI · PI JASON T BLACKARD · 2002 to 2026
$2.3M
NCATS NIH HHS UL1 TR001425NIDDK NIH HHS T35 DK060444NIGMS NIH HHS T32 GM063483NINDS NIH HHS R01 NS044080
6 · The paper itself

Abstract

The intercalated cells (ITCs) of the amygdala have been shown to be critical regulatory components of amygdalar circuits, which control appropriate fear responses. Despite this, the molecular processes guiding ITC development remain poorly understood. Here we establish the zinc finger transcription factor Tshz1 as a marker of ITCs during their migration from the dorsal lateral ganglionic eminence through maturity. Using germline and conditional knock-out (cKO) mouse models, we show that

Indexed as

Interpersonal RelationsAmygdalaAnimalsBehavior, AnimalDepressionExtinction, PsychologicalFearFemaleForkhead Transcription FactorsHomeodomain ProteinsInterneuronsMaleMiceMice, KnockoutMotor ActivityMutationForkhead Transcription FactorsFoxp2 protein, mouseHomeodomain ProteinsRepressor ProteinsTshz1 protein, mousebrain developmenttelencephalontranscription factor

Identifiers

PMID29255003
PMCPMC5792476
OpenAlexW2777350706

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.